Declining mortality rates in children admitted to ICU following HCT

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Declining mortality rates in children admitted to ICU following HCT. / Jensen, Marie Louise Naestholt; Nielsen, Jeppe Sylvest Angaard; Nielsen, Jonas; Lundstrom, Kaare Engell; Heilmann, Carsten; Ifversen, Marianne.

In: Pediatric Transplantation, Vol. 25, No. 5, e13946, 08.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jensen, MLN, Nielsen, JSA, Nielsen, J, Lundstrom, KE, Heilmann, C & Ifversen, M 2021, 'Declining mortality rates in children admitted to ICU following HCT', Pediatric Transplantation, vol. 25, no. 5, e13946. https://doi.org/10.1111/petr.13946

APA

Jensen, M. L. N., Nielsen, J. S. A., Nielsen, J., Lundstrom, K. E., Heilmann, C., & Ifversen, M. (2021). Declining mortality rates in children admitted to ICU following HCT. Pediatric Transplantation, 25(5), [e13946]. https://doi.org/10.1111/petr.13946

CBE

Jensen MLN, Nielsen JSA, Nielsen J, Lundstrom KE, Heilmann C, Ifversen M. 2021. Declining mortality rates in children admitted to ICU following HCT. Pediatric Transplantation. 25(5):Article e13946. https://doi.org/10.1111/petr.13946

MLA

Vancouver

Jensen MLN, Nielsen JSA, Nielsen J, Lundstrom KE, Heilmann C, Ifversen M. Declining mortality rates in children admitted to ICU following HCT. Pediatric Transplantation. 2021 Aug;25(5). e13946. https://doi.org/10.1111/petr.13946

Author

Jensen, Marie Louise Naestholt ; Nielsen, Jeppe Sylvest Angaard ; Nielsen, Jonas ; Lundstrom, Kaare Engell ; Heilmann, Carsten ; Ifversen, Marianne. / Declining mortality rates in children admitted to ICU following HCT. In: Pediatric Transplantation. 2021 ; Vol. 25, No. 5.

Bibtex

@article{2afff7587d514071818c2c0238df0d1f,
title = "Declining mortality rates in children admitted to ICU following HCT",
abstract = "We aimed to assess short- and long-term mortality, including factors associated with mortality, for children referred to a pediatric intensive care unit (ICU) at Rigshospitalet, Denmark, following haematopoietic cell transplantation (HCT). Data regarding admission to ICU and mortality following HCT for children below 16 years of age between 2000 and 2017 were retrospectively analyzed. We identified 55 ICU admissions in 39 patients following 46 HCTs. The overall in-ICU, in-hospital, 3-month, and 1-year mortality rates were 33.3%, 43.6%, 46.2%, and 51.3%, respectively. Patients admitted from 2000 to 2010 had a 3-month mortality of 63.2% and 1-year mortality of 68.4%, compared to 30% and 35% (P = .040 and P = .039) for patients admitted from 2011 to 2017. The main reason for ICU admission was respiratory failure (78.2%). Mechanical ventilation (MV) was associated with a higher long-term mortality (P = .044), and use of inotropes or vasopressors was associated with increased mortality at all times (all P > .006). Extracorporeal life support, renal replacement therapy, longer ICU stay, and longer time with MV were not associated with increased mortality. Over the past two decades, mortality was significantly reduced in pediatric HCT patients admitted to the ICU. The cause is probably multifactorial and warrants further studies. Our findings support admissions of critically ill pediatric HCT patients to intensive care with encouraging outcomes of even long-term admissions.",
keywords = "bone marrow transplantation, critical care, ECLS, hematology, mortality, pediatrics, STEM-CELL TRANSPLANT, INTENSIVE-CARE-UNIT, HEMATOPOIETIC SCT, RECIPIENTS, OUTCOMES, SUPPORT, DISEASE",
author = "Jensen, {Marie Louise Naestholt} and Nielsen, {Jeppe Sylvest Angaard} and Jonas Nielsen and Lundstrom, {Kaare Engell} and Carsten Heilmann and Marianne Ifversen",
year = "2021",
month = aug,
doi = "10.1111/petr.13946",
language = "English",
volume = "25",
journal = "Pediatric Transplantation",
issn = "1397-3142",
publisher = "Wiley-Blackwell Publishing, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Declining mortality rates in children admitted to ICU following HCT

AU - Jensen, Marie Louise Naestholt

AU - Nielsen, Jeppe Sylvest Angaard

AU - Nielsen, Jonas

AU - Lundstrom, Kaare Engell

AU - Heilmann, Carsten

AU - Ifversen, Marianne

PY - 2021/8

Y1 - 2021/8

N2 - We aimed to assess short- and long-term mortality, including factors associated with mortality, for children referred to a pediatric intensive care unit (ICU) at Rigshospitalet, Denmark, following haematopoietic cell transplantation (HCT). Data regarding admission to ICU and mortality following HCT for children below 16 years of age between 2000 and 2017 were retrospectively analyzed. We identified 55 ICU admissions in 39 patients following 46 HCTs. The overall in-ICU, in-hospital, 3-month, and 1-year mortality rates were 33.3%, 43.6%, 46.2%, and 51.3%, respectively. Patients admitted from 2000 to 2010 had a 3-month mortality of 63.2% and 1-year mortality of 68.4%, compared to 30% and 35% (P = .040 and P = .039) for patients admitted from 2011 to 2017. The main reason for ICU admission was respiratory failure (78.2%). Mechanical ventilation (MV) was associated with a higher long-term mortality (P = .044), and use of inotropes or vasopressors was associated with increased mortality at all times (all P > .006). Extracorporeal life support, renal replacement therapy, longer ICU stay, and longer time with MV were not associated with increased mortality. Over the past two decades, mortality was significantly reduced in pediatric HCT patients admitted to the ICU. The cause is probably multifactorial and warrants further studies. Our findings support admissions of critically ill pediatric HCT patients to intensive care with encouraging outcomes of even long-term admissions.

AB - We aimed to assess short- and long-term mortality, including factors associated with mortality, for children referred to a pediatric intensive care unit (ICU) at Rigshospitalet, Denmark, following haematopoietic cell transplantation (HCT). Data regarding admission to ICU and mortality following HCT for children below 16 years of age between 2000 and 2017 were retrospectively analyzed. We identified 55 ICU admissions in 39 patients following 46 HCTs. The overall in-ICU, in-hospital, 3-month, and 1-year mortality rates were 33.3%, 43.6%, 46.2%, and 51.3%, respectively. Patients admitted from 2000 to 2010 had a 3-month mortality of 63.2% and 1-year mortality of 68.4%, compared to 30% and 35% (P = .040 and P = .039) for patients admitted from 2011 to 2017. The main reason for ICU admission was respiratory failure (78.2%). Mechanical ventilation (MV) was associated with a higher long-term mortality (P = .044), and use of inotropes or vasopressors was associated with increased mortality at all times (all P > .006). Extracorporeal life support, renal replacement therapy, longer ICU stay, and longer time with MV were not associated with increased mortality. Over the past two decades, mortality was significantly reduced in pediatric HCT patients admitted to the ICU. The cause is probably multifactorial and warrants further studies. Our findings support admissions of critically ill pediatric HCT patients to intensive care with encouraging outcomes of even long-term admissions.

KW - bone marrow transplantation

KW - critical care

KW - ECLS

KW - hematology

KW - mortality

KW - pediatrics

KW - STEM-CELL TRANSPLANT

KW - INTENSIVE-CARE-UNIT

KW - HEMATOPOIETIC SCT

KW - RECIPIENTS

KW - OUTCOMES

KW - SUPPORT

KW - DISEASE

U2 - 10.1111/petr.13946

DO - 10.1111/petr.13946

M3 - Journal article

C2 - 33314484

VL - 25

JO - Pediatric Transplantation

JF - Pediatric Transplantation

SN - 1397-3142

IS - 5

M1 - e13946

ER -