Darkfield illumination improves microscopic detection of metals in Timm's stained tissue.

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  • Interdisciplinary Nanoscience Center
  • Department of Biological Sciences, Zoophysiology
Deposits of trace or toxic metals can be quickly identified by light microscopical surveys of tissue sections stained for metals by variants of Timm's silver enhancement method. The present work shows that the small, isolated silver grains that label isolated deposits of metal in tissue are undetectable in brightfield light microscopy but are easily detected in darkfield microscopy. Darkfield illumination is therefore recommended for improving the detection of trace or toxic metals in tissue.
Udgivelsesdato: 1989-Aug
Original languageEnglish
JournalJournal of Molecular Histology (Print Edition)
Volume21
Issue8
Pages (from-to)477-80
Number of pages3
ISSN1567-2379
Publication statusPublished - 1989

    Research areas

  • Animals, Metals, Microscopy, Olfactory Nerve, Silver, Staining and Labeling, Trout

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