DaPeCa-9 - cohabitation and socio-economic conditions predict penile cancer-specific survival in a national clinical study from Denmark

TY - JOUR

T1 - DaPeCa-9 - cohabitation and socio-economic conditions predict penile cancer-specific survival in a national clinical study from Denmark

AU - Baekhøj Kortsen, Dennis

AU - Predbjørn Krarup, Kim

AU - Jakobsen, Jakob Kristian

PY - 2021/12

Y1 - 2021/12

N2 - Background: Cohabitation and social conditions predict prognosis in several cancers; recent data suggest this might also be the case in penile cancer. Objective: To assess the prognostic significance of cohabitation, living arrangements and socio-economic conditions for cancer-specific survival (CSS) in patients with penile squamous cell carcinoma (pSCC) Methods: We retrospectively evaluated CSS in 429 pSCC patients from a 10-year period. We assessed cohabitation, living arrangements and socio-economic conditions(SEC) as prognostic predictors. Kaplan–Meier estimates and Cox hazard rates (HR) with 95% confidence intervals were used for analysis. Results: Out of 429 pSCC patients, 137 (32%) were living alone and 292 (68%) were cohabiting. With a Cox HR at 1.91 (95% CI 1.3–2.98) patients living alone had a significantly lower median five-year survival rate at 69% (95% CI 60-77%) compared to cohabiting patients at 83% (95% CI 78–87%), p = 0.002. Comparing 60 (14%) from higher to 202 (47%) from medium and 95 (22%) patients from lower socio-economic groups we found Cox HRs at 1, 2.4 (95% CI 1.0-5.7, p = 0.04) and 3.4 (95% CI 1.4-8.1, p < 0.01) respectively. When comparing living arrangements, the trend that patients living in apartments and institutions had poorer outcomes than patients living in a house did not reach statistical significance. Conclusions: Living alone and in poor socio-economic conditions predict poor prognosis in penile cancer in this national study. We make the case for further research in efforts to minimize cancer inequality pSCC patients.

AB - Background: Cohabitation and social conditions predict prognosis in several cancers; recent data suggest this might also be the case in penile cancer. Objective: To assess the prognostic significance of cohabitation, living arrangements and socio-economic conditions for cancer-specific survival (CSS) in patients with penile squamous cell carcinoma (pSCC) Methods: We retrospectively evaluated CSS in 429 pSCC patients from a 10-year period. We assessed cohabitation, living arrangements and socio-economic conditions(SEC) as prognostic predictors. Kaplan–Meier estimates and Cox hazard rates (HR) with 95% confidence intervals were used for analysis. Results: Out of 429 pSCC patients, 137 (32%) were living alone and 292 (68%) were cohabiting. With a Cox HR at 1.91 (95% CI 1.3–2.98) patients living alone had a significantly lower median five-year survival rate at 69% (95% CI 60-77%) compared to cohabiting patients at 83% (95% CI 78–87%), p = 0.002. Comparing 60 (14%) from higher to 202 (47%) from medium and 95 (22%) patients from lower socio-economic groups we found Cox HRs at 1, 2.4 (95% CI 1.0-5.7, p = 0.04) and 3.4 (95% CI 1.4-8.1, p < 0.01) respectively. When comparing living arrangements, the trend that patients living in apartments and institutions had poorer outcomes than patients living in a house did not reach statistical significance. Conclusions: Living alone and in poor socio-economic conditions predict poor prognosis in penile cancer in this national study. We make the case for further research in efforts to minimize cancer inequality pSCC patients.

KW - Penile cancer

KW - cancer-specific survival

KW - cohabitation

KW - living arrangements

KW - penile squamous cell carcinoma (pSCC)

KW - socio-economic conditions (SEC)

KW - Prognosis

KW - Humans

KW - Male

KW - Denmark/epidemiology

KW - Penile Neoplasms

KW - Retrospective Studies

KW - Home Environment

U2 - 10.1080/21681805.2021.1879928

DO - 10.1080/21681805.2021.1879928

M3 - Journal article

C2 - 33554693

SN - 2168-1805

VL - 55

SP - 486

EP - 490

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

IS - 6

ER -