Cut to the chase-Regulating translation through RNA cleavage

Nicholas Sofos; Kehan Xu; Emil Dedic; Ditlev E. Brodersen

doi:10.1016/j.biochi.2015.01.009

Cut to the chase-Regulating translation through RNA cleavage

Nicholas Sofos, Kehan Xu, Emil Dedic, Ditlev E. Brodersen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

13 Citations (Scopus)

Abstract

Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

Original language	English
Journal	Biochimie
Volume	114
Pages (from-to)	10-17
Number of pages	8
ISSN	0300-9084
DOIs	https://doi.org/10.1016/j.biochi.2015.01.009
Publication status	Published - Jul 2015

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10.1016/j.biochi.2015.01.009

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title = "Cut to the chase-Regulating translation through RNA cleavage",

abstract = "Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.",

author = "Nicholas Sofos and Kehan Xu and Emil Dedic and Brodersen, {Ditlev E.}",

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doi = "10.1016/j.biochi.2015.01.009",

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T1 - Cut to the chase-Regulating translation through RNA cleavage

AU - Sofos, Nicholas

AU - Xu, Kehan

AU - Dedic, Emil

AU - Brodersen, Ditlev E.

PY - 2015/7

Y1 - 2015/7

N2 - Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

AB - Activation of toxin-antitoxin (TA) systems provides an important mechanism for bacteria to adapt to challenging and ever changing environmental conditions. Known TA systems are classified into five families based on the mechanisms of antitoxin inhibition and toxin activity. For type II TA systems, the toxin is inactivated in exponentially growing cells by tightly binding its antitoxin partner protein, which also serves to regulate cellular levels of the complex through transcriptional auto-repression. During cellular stress, however, the antitoxin is degraded thus freeing the toxin, which is then able to regulate central cellular processes, primarily protein translation to adjust cell growth to the new conditions. In this review, we focus on the type II TA pairs that regulate protein translation through cleavage of ribosomal, transfer, or messenger RNA.

U2 - 10.1016/j.biochi.2015.01.009

DO - 10.1016/j.biochi.2015.01.009

M3 - Journal article

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SN - 0300-9084

VL - 114

SP - 10

EP - 17

JO - Biochimie

JF - Biochimie

ER -

Cut to the chase-Regulating translation through RNA cleavage

Abstract

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