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Current use of inotropes in circulatory shock

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Current use of inotropes in circulatory shock. / Scheeren, Thomas W.L.; Bakker, Jan; Kaufmann, Thomas; Annane, Djillali; Asfar, Pierre; Boerma, E. Christiaan; Cecconi, Maurizio; Chew, Michelle S.; Cholley, Bernard; Cronhjort, Maria; De Backer, Daniel; Dubin, Arnaldo; Dünser, Martin W.; Duranteau, Jacques; Gordon, Anthony C.; Hajjar, Ludhmila A.; Hamzaoui, Olfa; Hernandez, Glenn; Kanoore Edul, Vanina; Koster, Geert; Landoni, Giovanni; Leone, Marc; Levy, Bruno; Martin, Claude; Mebazaa, Alexandre; Monnet, Xavier; Morelli, Andrea; Payen, Didier; Pearse, Rupert M.; Pinsky, Michael R.; Radermacher, Peter; Reuter, Daniel A.; Sakr, Yasser; Sander, Michael; Saugel, Bernd; Singer, Mervyn; Squara, Pierre; Vieillard-Baron, Antoine; Vignon, Philippe; Vincent, Jean Louis; van der Horst, Iwan C.C.; Vistisen, Simon T.; Teboul, Jean Louis.

In: Annals of Intensive Care, Vol. 11, 21, 12.2021.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Scheeren, TWL, Bakker, J, Kaufmann, T, Annane, D, Asfar, P, Boerma, EC, Cecconi, M, Chew, MS, Cholley, B, Cronhjort, M, De Backer, D, Dubin, A, Dünser, MW, Duranteau, J, Gordon, AC, Hajjar, LA, Hamzaoui, O, Hernandez, G, Kanoore Edul, V, Koster, G, Landoni, G, Leone, M, Levy, B, Martin, C, Mebazaa, A, Monnet, X, Morelli, A, Payen, D, Pearse, RM, Pinsky, MR, Radermacher, P, Reuter, DA, Sakr, Y, Sander, M, Saugel, B, Singer, M, Squara, P, Vieillard-Baron, A, Vignon, P, Vincent, JL, van der Horst, ICC, Vistisen, ST & Teboul, JL 2021, 'Current use of inotropes in circulatory shock', Annals of Intensive Care, vol. 11, 21. https://doi.org/10.1186/s13613-021-00806-8

APA

Scheeren, T. W. L., Bakker, J., Kaufmann, T., Annane, D., Asfar, P., Boerma, E. C., Cecconi, M., Chew, M. S., Cholley, B., Cronhjort, M., De Backer, D., Dubin, A., Dünser, M. W., Duranteau, J., Gordon, A. C., Hajjar, L. A., Hamzaoui, O., Hernandez, G., Kanoore Edul, V., ... Teboul, J. L. (2021). Current use of inotropes in circulatory shock. Annals of Intensive Care, 11, [21]. https://doi.org/10.1186/s13613-021-00806-8

CBE

Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC, Cecconi M, Chew MS, Cholley B, Cronhjort M, De Backer D, Dubin A, Dünser MW, Duranteau J, Gordon AC, Hajjar LA, Hamzaoui O, Hernandez G, Kanoore Edul V, Koster G, Landoni G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse RM, Pinsky MR, Radermacher P, Reuter DA, Sakr Y, Sander M, Saugel B, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vincent JL, van der Horst ICC, Vistisen ST, Teboul JL. 2021. Current use of inotropes in circulatory shock. Annals of Intensive Care. 11:Article 21. https://doi.org/10.1186/s13613-021-00806-8

MLA

Scheeren, Thomas W.L. et al. "Current use of inotropes in circulatory shock". Annals of Intensive Care. 2021. 11. https://doi.org/10.1186/s13613-021-00806-8

Vancouver

Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC et al. Current use of inotropes in circulatory shock. Annals of Intensive Care. 2021 Dec;11. 21. https://doi.org/10.1186/s13613-021-00806-8

Author

Scheeren, Thomas W.L. ; Bakker, Jan ; Kaufmann, Thomas ; Annane, Djillali ; Asfar, Pierre ; Boerma, E. Christiaan ; Cecconi, Maurizio ; Chew, Michelle S. ; Cholley, Bernard ; Cronhjort, Maria ; De Backer, Daniel ; Dubin, Arnaldo ; Dünser, Martin W. ; Duranteau, Jacques ; Gordon, Anthony C. ; Hajjar, Ludhmila A. ; Hamzaoui, Olfa ; Hernandez, Glenn ; Kanoore Edul, Vanina ; Koster, Geert ; Landoni, Giovanni ; Leone, Marc ; Levy, Bruno ; Martin, Claude ; Mebazaa, Alexandre ; Monnet, Xavier ; Morelli, Andrea ; Payen, Didier ; Pearse, Rupert M. ; Pinsky, Michael R. ; Radermacher, Peter ; Reuter, Daniel A. ; Sakr, Yasser ; Sander, Michael ; Saugel, Bernd ; Singer, Mervyn ; Squara, Pierre ; Vieillard-Baron, Antoine ; Vignon, Philippe ; Vincent, Jean Louis ; van der Horst, Iwan C.C. ; Vistisen, Simon T. ; Teboul, Jean Louis. / Current use of inotropes in circulatory shock. In: Annals of Intensive Care. 2021 ; Vol. 11.

Bibtex

@article{c36b572ac9eb47d0b0c519b98244c583,
title = "Current use of inotropes in circulatory shock",
abstract = "Background: Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock. Methods: From November 2016 to April 2017, an anonymous web-based survey on the use of cardiovascular drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM). A total of 14 questions focused on the profile of respondents, the triggering factors, first-line choice, dosing, timing, targets, additional treatment strategy, and suggested effect of inotropes. In addition, a group of 42 international ESICM experts was asked to formulate recommendations for the use of inotropes based on 11 questions. Results: A total of 839 physicians from 82 countries responded. Dobutamine was the first-line inotrope in critically ill patients with acute heart failure for 84% of respondents. Two-thirds of respondents (66%) stated to use inotropes when there were persistent clinical signs of hypoperfusion or persistent hyperlactatemia despite a supposed adequate use of fluids and vasopressors, with (44%) or without (22%) the context of low left ventricular ejection fraction. Nearly half (44%) of respondents stated an adequate cardiac output as target for inotropic treatment. The experts agreed on 11 strong recommendations, all of which were based on excellent (> 90%) or good (81–90%) agreement. Recommendations include the indications for inotropes (septic and cardiogenic shock), the choice of drugs (dobutamine, not dopamine), the triggers (low cardiac output and clinical signs of hypoperfusion) and targets (adequate cardiac output) and stopping criteria (adverse effects and clinical improvement). Conclusion: Inotrope use in critically ill patients is quite heterogeneous as self-reported by individual caregivers. Eleven strong recommendations on the indications, choice, triggers and targets for the use of inotropes are given by international experts. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock that encompasses individualized targets and outcomes.",
keywords = "Acute circulatory failure, Cardiac output, Cardiogenic shock, Catecholamines, Inotropes, Levosimendan, PDE-inhibitors, Resuscitation, Sepsis, Septic shock, Vasoactive agents",
author = "Scheeren, {Thomas W.L.} and Jan Bakker and Thomas Kaufmann and Djillali Annane and Pierre Asfar and Boerma, {E. Christiaan} and Maurizio Cecconi and Chew, {Michelle S.} and Bernard Cholley and Maria Cronhjort and {De Backer}, Daniel and Arnaldo Dubin and D{\"u}nser, {Martin W.} and Jacques Duranteau and Gordon, {Anthony C.} and Hajjar, {Ludhmila A.} and Olfa Hamzaoui and Glenn Hernandez and {Kanoore Edul}, Vanina and Geert Koster and Giovanni Landoni and Marc Leone and Bruno Levy and Claude Martin and Alexandre Mebazaa and Xavier Monnet and Andrea Morelli and Didier Payen and Pearse, {Rupert M.} and Pinsky, {Michael R.} and Peter Radermacher and Reuter, {Daniel A.} and Yasser Sakr and Michael Sander and Bernd Saugel and Mervyn Singer and Pierre Squara and Antoine Vieillard-Baron and Philippe Vignon and Vincent, {Jean Louis} and {van der Horst}, {Iwan C.C.} and Vistisen, {Simon T.} and Teboul, {Jean Louis}",
note = "Funding Information: This work has received the endorsement of the European Society of Intensive Care Medicine. The authors would like to thank Hannah Wunsch and Anders Perner, who provided their expertise as experts but abstained from being listed as co-author of this paper. Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = dec,
doi = "10.1186/s13613-021-00806-8",
language = "English",
volume = "11",
journal = "Annals of Intensive Care",
issn = "2110-5820",
publisher = "SpringerOpen",

}

RIS

TY - JOUR

T1 - Current use of inotropes in circulatory shock

AU - Scheeren, Thomas W.L.

AU - Bakker, Jan

AU - Kaufmann, Thomas

AU - Annane, Djillali

AU - Asfar, Pierre

AU - Boerma, E. Christiaan

AU - Cecconi, Maurizio

AU - Chew, Michelle S.

AU - Cholley, Bernard

AU - Cronhjort, Maria

AU - De Backer, Daniel

AU - Dubin, Arnaldo

AU - Dünser, Martin W.

AU - Duranteau, Jacques

AU - Gordon, Anthony C.

AU - Hajjar, Ludhmila A.

AU - Hamzaoui, Olfa

AU - Hernandez, Glenn

AU - Kanoore Edul, Vanina

AU - Koster, Geert

AU - Landoni, Giovanni

AU - Leone, Marc

AU - Levy, Bruno

AU - Martin, Claude

AU - Mebazaa, Alexandre

AU - Monnet, Xavier

AU - Morelli, Andrea

AU - Payen, Didier

AU - Pearse, Rupert M.

AU - Pinsky, Michael R.

AU - Radermacher, Peter

AU - Reuter, Daniel A.

AU - Sakr, Yasser

AU - Sander, Michael

AU - Saugel, Bernd

AU - Singer, Mervyn

AU - Squara, Pierre

AU - Vieillard-Baron, Antoine

AU - Vignon, Philippe

AU - Vincent, Jean Louis

AU - van der Horst, Iwan C.C.

AU - Vistisen, Simon T.

AU - Teboul, Jean Louis

N1 - Funding Information: This work has received the endorsement of the European Society of Intensive Care Medicine. The authors would like to thank Hannah Wunsch and Anders Perner, who provided their expertise as experts but abstained from being listed as co-author of this paper. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/12

Y1 - 2021/12

N2 - Background: Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock. Methods: From November 2016 to April 2017, an anonymous web-based survey on the use of cardiovascular drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM). A total of 14 questions focused on the profile of respondents, the triggering factors, first-line choice, dosing, timing, targets, additional treatment strategy, and suggested effect of inotropes. In addition, a group of 42 international ESICM experts was asked to formulate recommendations for the use of inotropes based on 11 questions. Results: A total of 839 physicians from 82 countries responded. Dobutamine was the first-line inotrope in critically ill patients with acute heart failure for 84% of respondents. Two-thirds of respondents (66%) stated to use inotropes when there were persistent clinical signs of hypoperfusion or persistent hyperlactatemia despite a supposed adequate use of fluids and vasopressors, with (44%) or without (22%) the context of low left ventricular ejection fraction. Nearly half (44%) of respondents stated an adequate cardiac output as target for inotropic treatment. The experts agreed on 11 strong recommendations, all of which were based on excellent (> 90%) or good (81–90%) agreement. Recommendations include the indications for inotropes (septic and cardiogenic shock), the choice of drugs (dobutamine, not dopamine), the triggers (low cardiac output and clinical signs of hypoperfusion) and targets (adequate cardiac output) and stopping criteria (adverse effects and clinical improvement). Conclusion: Inotrope use in critically ill patients is quite heterogeneous as self-reported by individual caregivers. Eleven strong recommendations on the indications, choice, triggers and targets for the use of inotropes are given by international experts. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock that encompasses individualized targets and outcomes.

AB - Background: Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock. Methods: From November 2016 to April 2017, an anonymous web-based survey on the use of cardiovascular drugs was accessible to members of the European Society of Intensive Care Medicine (ESICM). A total of 14 questions focused on the profile of respondents, the triggering factors, first-line choice, dosing, timing, targets, additional treatment strategy, and suggested effect of inotropes. In addition, a group of 42 international ESICM experts was asked to formulate recommendations for the use of inotropes based on 11 questions. Results: A total of 839 physicians from 82 countries responded. Dobutamine was the first-line inotrope in critically ill patients with acute heart failure for 84% of respondents. Two-thirds of respondents (66%) stated to use inotropes when there were persistent clinical signs of hypoperfusion or persistent hyperlactatemia despite a supposed adequate use of fluids and vasopressors, with (44%) or without (22%) the context of low left ventricular ejection fraction. Nearly half (44%) of respondents stated an adequate cardiac output as target for inotropic treatment. The experts agreed on 11 strong recommendations, all of which were based on excellent (> 90%) or good (81–90%) agreement. Recommendations include the indications for inotropes (septic and cardiogenic shock), the choice of drugs (dobutamine, not dopamine), the triggers (low cardiac output and clinical signs of hypoperfusion) and targets (adequate cardiac output) and stopping criteria (adverse effects and clinical improvement). Conclusion: Inotrope use in critically ill patients is quite heterogeneous as self-reported by individual caregivers. Eleven strong recommendations on the indications, choice, triggers and targets for the use of inotropes are given by international experts. Future studies should focus on consistent indications for inotrope use and implementation into a guideline for circulatory shock that encompasses individualized targets and outcomes.

KW - Acute circulatory failure

KW - Cardiac output

KW - Cardiogenic shock

KW - Catecholamines

KW - Inotropes

KW - Levosimendan

KW - PDE-inhibitors

KW - Resuscitation

KW - Sepsis

KW - Septic shock

KW - Vasoactive agents

UR - http://www.scopus.com/inward/record.url?scp=85100119101&partnerID=8YFLogxK

U2 - 10.1186/s13613-021-00806-8

DO - 10.1186/s13613-021-00806-8

M3 - Journal article

C2 - 33512597

AN - SCOPUS:85100119101

VL - 11

JO - Annals of Intensive Care

JF - Annals of Intensive Care

SN - 2110-5820

M1 - 21

ER -