Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish

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The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97Å) and adopts an overall globular shape. Two antiparallel β-sheets form a central β-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures
Original languageEnglish
JournalProteins: Structure, Function, and Bioinformatics
Volume80
Issue6
Pages (from-to)1694-1698
Number of pages5
ISSN0887-3585
DOIs
Publication statusPublished - Jun 2012

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