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Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

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Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. / Ardenkjær-Larsen, Jan Henrik; Bowen, Sean; Petersen, Jan Raagaard et al.

In: Magnetic Resonance in Medicine, Vol. 81, No. 3, 01.03.2019, p. 2184-2194.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Ardenkjær-Larsen, JH, Bowen, S, Petersen, JR, Rybalko, O, Vinding, MS, Ullisch, M & Nielsen, NC 2019, 'Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T', Magnetic Resonance in Medicine, vol. 81, no. 3, pp. 2184-2194. https://doi.org/10.1002/mrm.27537

APA

Ardenkjær-Larsen, J. H., Bowen, S., Petersen, J. R., Rybalko, O., Vinding, M. S., Ullisch, M., & Nielsen, N. C. (2019). Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. Magnetic Resonance in Medicine, 81(3), 2184-2194. https://doi.org/10.1002/mrm.27537

CBE

Ardenkjær-Larsen JH, Bowen S, Petersen JR, Rybalko O, Vinding MS, Ullisch M, Nielsen NC. 2019. Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. Magnetic Resonance in Medicine. 81(3):2184-2194. https://doi.org/10.1002/mrm.27537

MLA

Ardenkjær-Larsen, Jan Henrik et al. "Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T". Magnetic Resonance in Medicine. 2019, 81(3). 2184-2194. https://doi.org/10.1002/mrm.27537

Vancouver

Ardenkjær-Larsen JH, Bowen S, Petersen JR, Rybalko O, Vinding MS, Ullisch M et al. Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. Magnetic Resonance in Medicine. 2019 Mar 1;81(3):2184-2194. doi: 10.1002/mrm.27537

Author

Ardenkjær-Larsen, Jan Henrik ; Bowen, Sean ; Petersen, Jan Raagaard et al. / Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T. In: Magnetic Resonance in Medicine. 2019 ; Vol. 81, No. 3. pp. 2184-2194.

Bibtex

@article{c8f2c37395964dbaa535f4af93b68ae5,
title = "Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T",
abstract = "Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. Method: It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. Results: It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. Conclusion: We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.",
keywords = "dissolution dynamic nuclear polarization, dry magnet, hyperpolarization, polarizer, RESONANCE",
author = "Ardenkj{\ae}r-Larsen, {Jan Henrik} and Sean Bowen and Petersen, {Jan Raagaard} and Oleksandr Rybalko and Vinding, {Mads Sloth} and Marcus Ullisch and Nielsen, {Niels Chr}",
year = "2019",
month = mar,
day = "1",
doi = "10.1002/mrm.27537",
language = "English",
volume = "81",
pages = "2184--2194",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Cryogen-free dissolution dynamic nuclear polarization polarizer operating at 3.35 T, 6.70 T, and 10.1 T

AU - Ardenkjær-Larsen, Jan Henrik

AU - Bowen, Sean

AU - Petersen, Jan Raagaard

AU - Rybalko, Oleksandr

AU - Vinding, Mads Sloth

AU - Ullisch, Marcus

AU - Nielsen, Niels Chr

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. Method: It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. Results: It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. Conclusion: We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.

AB - Purpose: A novel dissolution dynamic nuclear polarization (dDNP) polarizer platform is presented. The polarizer meets a number of key requirements for in vitro, preclinical, and clinical applications. Method: It uses no liquid cryogens, operates in continuous mode, accommodates a wide range of sample sizes up to and including those required for human studies, and is fully automated. Results: It offers a wide operational window both in terms of magnetic field, up to 10.1 T, and temperature, from room temperature down to 1.3 K. The polarizer delivers a 13C liquid state polarization for [1-13C]pyruvate of 70%. The build-up time constant in the solid state is approximately 1200 s (20 minutes), allowing a sample throughput of at least one sample per hour including sample loading and dissolution. Conclusion: We confirm the previously reported strong field dependence in the range 3.35 to 6.7 T, but see no further increase in polarization when increasing the magnetic field strength to 10.1 T for [1-13C]pyruvate and trityl. Using a custom dry magnet, cold head and recondensing, closed-cycle cooling system, combined with a modular DNP probe, and automation and fluid handling systems, we have designed a unique dDNP system with unrivalled flexibility and performance.

KW - dissolution dynamic nuclear polarization

KW - dry magnet

KW - hyperpolarization

KW - polarizer

KW - RESONANCE

UR - http://www.scopus.com/inward/record.url?scp=85055416410&partnerID=8YFLogxK

U2 - 10.1002/mrm.27537

DO - 10.1002/mrm.27537

M3 - Journal article

C2 - 30357898

AN - SCOPUS:85055416410

VL - 81

SP - 2184

EP - 2194

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 3

ER -