Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

TY - JOUR

T1 - Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

AU - Zevini, Alessandra

AU - Olagnier, David

AU - Hiscottt, John

PY - 2017/3

Y1 - 2017/3

N2 - Detection of evolutionarily conserved molecules on microbial pathogens by host immune sensors represents the initial trigger of the immune response against infection. Cytosolic receptors sense viral and intracellular bacterial genomes, as well as nucleic acids produced during replication. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Although distinct classes of receptors are responsible for the RNA and DNA sensing, the downstream signaling components are physically and functionally interconnected. This review highlights the importance of the crosstalk between retinoic acid inducible gene-I (RIG-I)-mitochondrial antiviral-signaling protein (MAVS) RNA sensing and the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA sensing pathways in potentiating efficient antiviral responses. The potential of cGAS-STING manipulation as a component of cancer immunotherapy is also reviewed.

AB - Detection of evolutionarily conserved molecules on microbial pathogens by host immune sensors represents the initial trigger of the immune response against infection. Cytosolic receptors sense viral and intracellular bacterial genomes, as well as nucleic acids produced during replication. Once activated, these sensors trigger multiple signaling cascades, converging on the production of type I interferons and proinflammatory cytokines. Although distinct classes of receptors are responsible for the RNA and DNA sensing, the downstream signaling components are physically and functionally interconnected. This review highlights the importance of the crosstalk between retinoic acid inducible gene-I (RIG-I)-mitochondrial antiviral-signaling protein (MAVS) RNA sensing and the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA sensing pathways in potentiating efficient antiviral responses. The potential of cGAS-STING manipulation as a component of cancer immunotherapy is also reviewed.

KW - GMP-AMP SYNTHASE

KW - DEPENDENT INNATE IMMUNITY

KW - CYTOSOLIC DNA SENSOR

KW - CYCLIC DI-GMP

KW - INTERFERON RESPONSE

KW - ANTIVIRAL RESPONSE

KW - IMMUNOGENIC TUMORS

KW - INTRACELLULAR DNA

KW - MELANOMA-CELLS

KW - CUTTING EDGE

U2 - 10.1016/j.it.2016.12.004

DO - 10.1016/j.it.2016.12.004

M3 - Review

C2 - 28073693

SN - 1471-4906

VL - 38

SP - 194

EP - 205

JO - Trends in Immunology

JF - Trends in Immunology

IS - 3

ER -