Creating carbon-carbon bonds with samarium diiodide for the synthesis of modified amino acids and peptides

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  • iNano-School
  • Interdisciplinary Nanoscience Center
  • Department of Chemistry
In this perspective, an overview of our experiences on the application of samarium diiodide in organic synthesis for the preparation of amino acid and peptide analogues is presented. Three different carbon-carbon bond forming reactions are discussed, including side chain introductions, gamma-amino acid synthesis and acyl-like radical additions for the construction of C-C mimics of the peptidic bonds.
Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume4
Issue19
Pages (from-to)3553-64
Number of pages12
ISSN1477-0520
DOIs
Publication statusPublished - 7 Oct 2006

    Research areas

  • Alkylation, Amides, Amino Acids, Carbon, Esters, Fumarates, Glycine, Glycosylation, Iodides, Ketones, Nitrogen, Peptides, Samarium

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