Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances

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Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. / Grist, James T; Hansen, Esben S S; Sánchez-Heredia, Juan D; McLean, Mary A; Tougaard, Rasmus; Riemer, Frank; Schulte, Rolf F; Kaggie, Joshua D; Ardenkjaer-Larsen, Jan Henrik; Laustsen, Christoffer; Gallagher, Ferdia A.

In: Magnetic Resonance in Medicine, Vol. 84, No. 4, 2020, p. 1817-1827.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Grist, JT, Hansen, ESS, Sánchez-Heredia, JD, McLean, MA, Tougaard, R, Riemer, F, Schulte, RF, Kaggie, JD, Ardenkjaer-Larsen, JH, Laustsen, C & Gallagher, FA 2020, 'Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances', Magnetic Resonance in Medicine, vol. 84, no. 4, pp. 1817-1827. https://doi.org/10.1002/mrm.28238

APA

Grist, J. T., Hansen, E. S. S., Sánchez-Heredia, J. D., McLean, M. A., Tougaard, R., Riemer, F., Schulte, R. F., Kaggie, J. D., Ardenkjaer-Larsen, J. H., Laustsen, C., & Gallagher, F. A. (2020). Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. Magnetic Resonance in Medicine, 84(4), 1817-1827. https://doi.org/10.1002/mrm.28238

CBE

Grist JT, Hansen ESS, Sánchez-Heredia JD, McLean MA, Tougaard R, Riemer F, Schulte RF, Kaggie JD, Ardenkjaer-Larsen JH, Laustsen C, Gallagher FA. 2020. Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. Magnetic Resonance in Medicine. 84(4):1817-1827. https://doi.org/10.1002/mrm.28238

MLA

Vancouver

Grist JT, Hansen ESS, Sánchez-Heredia JD, McLean MA, Tougaard R, Riemer F et al. Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. Magnetic Resonance in Medicine. 2020;84(4):1817-1827. https://doi.org/10.1002/mrm.28238

Author

Grist, James T ; Hansen, Esben S S ; Sánchez-Heredia, Juan D ; McLean, Mary A ; Tougaard, Rasmus ; Riemer, Frank ; Schulte, Rolf F ; Kaggie, Joshua D ; Ardenkjaer-Larsen, Jan Henrik ; Laustsen, Christoffer ; Gallagher, Ferdia A. / Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances. In: Magnetic Resonance in Medicine. 2020 ; Vol. 84, No. 4. pp. 1817-1827.

Bibtex

@article{d26ad5bfe2474ee0a61f90dfe96db497,
title = "Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances",
abstract = "PURPOSE: Calibration of hyperpolarized 13 C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13 C-enriched external phantoms. This study investigated the feasibility of using either 23 Na-MRI or 1 H-MRI to calibrate the 13 C excitation.METHODS: Commercial 13 C-coils were used to estimate the transmit gain and center frequency for 13 C and 23 Na resonances. Simulations of the transmit B1 profile of a Helmholtz loop were performed. Noise correlation was measured for both nuclei. A retrospective analysis of human data assessing the use of the 1 H resonance to predict [1-13 C]pyruvate center frequency was also performed. In vivo experiments were undertaken in the lower limbs of 6 pigs following injection of hyperpolarized 13 C-pyruvate.RESULTS: The difference in center frequencies and transmit gain between tissue 23 Na and [1-13 C]pyruvate was reproducible, with a mean scale factor of 1.05179 ± 0.00001 and 10.4 ± 0.2 dB, respectively. Utilizing the 1 H water peak, it was possible to retrospectively predict the 13 C-pyruvate center frequency with a standard deviation of only 11 Hz sufficient for spectral-spatial excitation-based studies.CONCLUSION: We demonstrate the feasibility of using the 23 Na and 1 H resonances to calibrate the 13 C transmit B1 using commercially available 13 C-coils. The method provides a simple approach for in vivo calibration and could improve clinical workflow.",
author = "Grist, {James T} and Hansen, {Esben S S} and S{\'a}nchez-Heredia, {Juan D} and McLean, {Mary A} and Rasmus Tougaard and Frank Riemer and Schulte, {Rolf F} and Kaggie, {Joshua D} and Ardenkjaer-Larsen, {Jan Henrik} and Christoffer Laustsen and Gallagher, {Ferdia A}",
note = "{\textcopyright} 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.",
year = "2020",
doi = "10.1002/mrm.28238",
language = "English",
volume = "84",
pages = "1817--1827",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances

AU - Grist, James T

AU - Hansen, Esben S S

AU - Sánchez-Heredia, Juan D

AU - McLean, Mary A

AU - Tougaard, Rasmus

AU - Riemer, Frank

AU - Schulte, Rolf F

AU - Kaggie, Joshua D

AU - Ardenkjaer-Larsen, Jan Henrik

AU - Laustsen, Christoffer

AU - Gallagher, Ferdia A

N1 - © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

PY - 2020

Y1 - 2020

N2 - PURPOSE: Calibration of hyperpolarized 13 C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13 C-enriched external phantoms. This study investigated the feasibility of using either 23 Na-MRI or 1 H-MRI to calibrate the 13 C excitation.METHODS: Commercial 13 C-coils were used to estimate the transmit gain and center frequency for 13 C and 23 Na resonances. Simulations of the transmit B1 profile of a Helmholtz loop were performed. Noise correlation was measured for both nuclei. A retrospective analysis of human data assessing the use of the 1 H resonance to predict [1-13 C]pyruvate center frequency was also performed. In vivo experiments were undertaken in the lower limbs of 6 pigs following injection of hyperpolarized 13 C-pyruvate.RESULTS: The difference in center frequencies and transmit gain between tissue 23 Na and [1-13 C]pyruvate was reproducible, with a mean scale factor of 1.05179 ± 0.00001 and 10.4 ± 0.2 dB, respectively. Utilizing the 1 H water peak, it was possible to retrospectively predict the 13 C-pyruvate center frequency with a standard deviation of only 11 Hz sufficient for spectral-spatial excitation-based studies.CONCLUSION: We demonstrate the feasibility of using the 23 Na and 1 H resonances to calibrate the 13 C transmit B1 using commercially available 13 C-coils. The method provides a simple approach for in vivo calibration and could improve clinical workflow.

AB - PURPOSE: Calibration of hyperpolarized 13 C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13 C-enriched external phantoms. This study investigated the feasibility of using either 23 Na-MRI or 1 H-MRI to calibrate the 13 C excitation.METHODS: Commercial 13 C-coils were used to estimate the transmit gain and center frequency for 13 C and 23 Na resonances. Simulations of the transmit B1 profile of a Helmholtz loop were performed. Noise correlation was measured for both nuclei. A retrospective analysis of human data assessing the use of the 1 H resonance to predict [1-13 C]pyruvate center frequency was also performed. In vivo experiments were undertaken in the lower limbs of 6 pigs following injection of hyperpolarized 13 C-pyruvate.RESULTS: The difference in center frequencies and transmit gain between tissue 23 Na and [1-13 C]pyruvate was reproducible, with a mean scale factor of 1.05179 ± 0.00001 and 10.4 ± 0.2 dB, respectively. Utilizing the 1 H water peak, it was possible to retrospectively predict the 13 C-pyruvate center frequency with a standard deviation of only 11 Hz sufficient for spectral-spatial excitation-based studies.CONCLUSION: We demonstrate the feasibility of using the 23 Na and 1 H resonances to calibrate the 13 C transmit B1 using commercially available 13 C-coils. The method provides a simple approach for in vivo calibration and could improve clinical workflow.

U2 - 10.1002/mrm.28238

DO - 10.1002/mrm.28238

M3 - Journal article

C2 - 32167199

VL - 84

SP - 1817

EP - 1827

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -