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COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry
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DOI
- https://doi.org/10.1021/acs.orglett.9b01423
Final published version
- Hugo Collin, Universidade Federal de Sao Joao del-Rei, Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark. ,
- Wallace Reis, UFMG ,
- Dennis Ulsøe Nielsen, Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark. ,
- Anders Thyboe Lindhardt, Danish Technological Institute, Aarhus C ,
- Marcelo Valle, Universidade Federal de Sao Joao del-Rei, Brazil
- Rossimiriam Freitas, UFMG, Brazil
- Troels Skrydstrup
Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
| Original language | English |
|---|---|
| Journal | Organic Letters |
| Volume | 21 |
| Issue | 15 |
| Pages (from-to) | 5775-5778 |
| Number of pages | 4 |
| ISSN | 1523-7060 |
| DOIs | |
| Publication status | Published - May 2019 |
- 4-COMPONENT SYNTHESIS, ARYL BROMIDES, COUPLING REACTIONS, DELIVERY, HALIDES, METATHESIS, PARAFFIN, POTASSIUM HYDRIDE, REAGENTS, USEFUL BASE
Research areas
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