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Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

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Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.
Original languageEnglish
Publication yearJul 2015
Number of pages2
Publication statusPublished - Jul 2015
EventThe Alzheimer's Association International Conference 2015 - Walter E. Washington Convention Center, Washington D.C., United States
Duration: 18 Jul 201523 Jul 2015


ConferenceThe Alzheimer's Association International Conference 2015
LocationWalter E. Washington Convention Center
CountryUnited States
CityWashington D.C.

Bibliographical note

doi: 10.1016/j.jalz.2015.06.1767

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ID: 95967955