Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

Simon Fristed Eskildsen; Louise Gyldensted; Kartheeban Nagenthiraja; Mikkel Bo Hansen; Rikke Beese Dalby; Jesper Frandsen; Anders Rodell; Carsten Gyldensted; Sune Nørhøj Jespersen; Kim Mouridsen; Hans Brændgaard; Leif Østergaard

doi:10.1016/j.jalz.2015.06.1767

Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

Simon Fristed Eskildsen, Louise Gyldensted, Kartheeban Nagenthiraja, Mikkel Bo Hansen, Rikke Beese Dalby, Jesper Frandsen, Anders Rodell, Carsten Gyldensted, Sune Nørhøj Jespersen, Kim Mouridsen, Hans Brændgaard, Leif Østergaard

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Abstract

Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.

Original language	English
Publication date	Jul 2015
Number of pages	2
DOIs	https://doi.org/10.1016/j.jalz.2015.06.1767
Publication status	Published - Jul 2015
Event	The Alzheimer's Association International Conference 2015 - Walter E. Washington Convention Center, Washington D.C., United States Duration: 18 Jul 2015 → 23 Jul 2015

Conference

Conference	The Alzheimer's Association International Conference 2015
Location	Walter E. Washington Convention Center
Country/Territory	United States
City	Washington D.C.
Period	18/07/2015 → 23/07/2015

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10.1016/j.jalz.2015.06.1767

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Eskildsen, S. F., Gyldensted, L., Nagenthiraja, K., Hansen, M. B., Dalby, R. B., Frandsen, J., Rodell, A., Gyldensted, C., Jespersen, S. N., Mouridsen, K., Brændgaard, H., & Østergaard, L. (2015). Cortical capillary dysfunction in patients suspected of Alzheimer’s disease. Abstract from The Alzheimer's Association International Conference 2015, Washington D.C., United States. https://doi.org/10.1016/j.jalz.2015.06.1767

@conference{94e9ef76ef8040e290434e95562214de,

title = "Cortical capillary dysfunction in patients suspected of Alzheimer{\textquoteright}s disease",

abstract = "Vascular risk factors are suspected to play a role in the etiology of Alzheimer{\textquoteright}s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.",

author = "Eskildsen, {Simon Fristed} and Louise Gyldensted and Kartheeban Nagenthiraja and Hansen, {Mikkel Bo} and Dalby, {Rikke Beese} and Jesper Frandsen and Anders Rodell and Carsten Gyldensted and Jespersen, {Sune N{\o}rh{\o}j} and Kim Mouridsen and Hans Br{\ae}ndgaard and Leif {\O}stergaard",

note = "doi: 10.1016/j.jalz.2015.06.1767; The Alzheimer's Association International Conference 2015, AAIC2015 ; Conference date: 18-07-2015 Through 23-07-2015",

year = "2015",

month = jul,

doi = "10.1016/j.jalz.2015.06.1767",

language = "English",

}

Eskildsen, SF, Gyldensted, L, Nagenthiraja, K, Hansen, MB , Dalby, RB, Frandsen, J, Rodell, A, Gyldensted, C , Jespersen, SN , Mouridsen, K, Brændgaard, H & Østergaard, L 2015, 'Cortical capillary dysfunction in patients suspected of Alzheimer’s disease', The Alzheimer's Association International Conference 2015, Washington D.C., United States, 18/07/2015 - 23/07/2015. https://doi.org/10.1016/j.jalz.2015.06.1767

Cortical capillary dysfunction in patients suspected of Alzheimer’s disease. / Eskildsen, Simon Fristed; Gyldensted, Louise; Nagenthiraja, Kartheeban et al.
2015. Abstract from The Alzheimer's Association International Conference 2015, Washington D.C., United States.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

TY - ABST

T1 - Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

AU - Eskildsen, Simon Fristed

AU - Gyldensted, Louise

AU - Nagenthiraja, Kartheeban

AU - Hansen, Mikkel Bo

AU - Dalby, Rikke Beese

AU - Frandsen, Jesper

AU - Rodell, Anders

AU - Gyldensted, Carsten

AU - Jespersen, Sune Nørhøj

AU - Mouridsen, Kim

AU - Brændgaard, Hans

AU - Østergaard, Leif

N1 - doi: 10.1016/j.jalz.2015.06.1767

PY - 2015/7

Y1 - 2015/7

N2 - Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.

AB - Vascular risk factors are suspected to play a role in the etiology of Alzheimer’s disease. Recently, a model that relates capillary dysfunction to the development of AD was proposed[1]. The model predicts that capillary dysfunction in form of increased capillary transit time heterogeneity (CTH) leads to inefficient oxygen extraction and eventually to tissue hypoxia. In this study we investigated regional cerebral blood flow (CBF) and CTH in cortical gray matter of AD patients and controls using dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) and surface based statistics.

U2 - 10.1016/j.jalz.2015.06.1767

DO - 10.1016/j.jalz.2015.06.1767

M3 - Conference abstract for conference

T2 - The Alzheimer's Association International Conference 2015

Y2 - 18 July 2015 through 23 July 2015

ER -

Cortical capillary dysfunction in patients suspected of Alzheimer’s disease

Abstract

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