Abstract
OBJECTIVE: To evaluate the association between patients' organ-specific co-morbidities and post-operative complications following radical cystectomy for bladder cancer.
PATIENTS AND METHODS: All patients who underwent radical cystectomy at Aarhus University Hospital during the period from January 2006 to February 2014 were included retrospectively. A total of 40 comorbidities and 59 complications were registered meticulously. Univariate and multivariate analyses were used to detect associations between the individual comorbidities and specific post-operative complications.
RESULTS: Ninety-two per cent (575/625) of patients experienced one or more complications following radical cystectomy. Clavien-Dindo grade 3-5 complications were observed in 40.8% of patients, and 6.2% had severe complications (Clavien-Dindo grade 4-5). The mortality rate was 2.2%. High BM, previous myocardial infarction and chronic obstructive pulmonary disease were noted to be associated with moderate-to-severe post-operative complications (Clavien-Dindo grade 3-5), while diabetes and lymphoproliferative disorders were significantly associated with severe complications (Clavien-Dindo grade 4-5).
CONCLUSION: This study demonstrates that overall complications to radical cystectomy are high (92%). The associations between specific comorbidities and complications need to be further investigated in order to evaluate whether pre-operative assessment can be more optimally used in a prevention strategy tailored to the individual patient.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Urology |
| Volume | 52 |
| Issue | 5-6 |
| Pages (from-to) | 395-400 |
| Number of pages | 6 |
| ISSN | 2168-1805 |
| DOIs | |
| Publication status | Published - 2018 |
Keywords
- Bladder cancer
- co-morbidities
- complications
- cystectomy
- MORTALITY
- PERFORMANCE
- COMORBIDITY
- IMPACT
- PREDICTORS
- COHORT
- OUTCOMES
- ASSOCIATION
- INDEXES
- Multivariate Analysis
- Age Factors
- Humans
- Middle Aged
- Salvage Therapy
- Male
- Diabetes Mellitus, Type 2/epidemiology
- Lymphoproliferative Disorders/epidemiology
- Pulmonary Disease, Chronic Obstructive/epidemiology
- Postoperative Complications/epidemiology
- Aged, 80 and over
- Adult
- Female
- Renal Insufficiency, Chronic/epidemiology
- Retrospective Studies
- Urinary Bladder Neoplasms/epidemiology
- Carcinoma, Transitional Cell/epidemiology
- Severity of Illness Index
- Myocardial Infarction/epidemiology
- Comorbidity
- Cardiovascular Diseases/epidemiology
- Obesity/epidemiology
- Hypertension/epidemiology
- Urinary Diversion/statistics & numerical data
- Cystectomy/methods
- Aged