TY - JOUR
T1 - Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study
AU - Horsager, Jacob
AU - Andersen, Katrine B
AU - Okkels, Niels
AU - Knudsen, Karoline
AU - Skjærbæk, Casper
AU - Van Den Berge, Nathalie
AU - Pavese, Nicola
AU - Gottrup, Hanne
AU - Borghammer, Per
N1 - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2024/10
Y1 - 2024/10
N2 - INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.
AB - INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.
KW - Asymmetry
KW - Imaging
KW - Lewy body dementia
KW - Lewy body disease
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=85202778026&partnerID=8YFLogxK
U2 - 10.1016/j.parkreldis.2024.107117
DO - 10.1016/j.parkreldis.2024.107117
M3 - Journal article
C2 - 39217795
SN - 1353-8020
VL - 127
SP - 107117
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
M1 - 107117
ER -