Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study

Jacob Horsager; Katrine B Andersen; Niels Okkels; Karoline Knudsen; Casper Skjærbæk; Nathalie Van Den Berge; Nicola Pavese; Hanne Gottrup; Per Borghammer

doi:10.1016/j.parkreldis.2024.107117

Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study

Jacob Horsager^*, Katrine B Andersen, Niels Okkels, Karoline Knudsen, Casper Skjærbæk, Nathalie Van Den Berge, Nicola Pavese, Hanne Gottrup, Per Borghammer

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.

METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.

RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.

CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.

Original language	English
Article number	107117
Journal	Parkinsonism & Related Disorders
Volume	127
Pages (from-to)	107117
ISSN	1353-8020
DOIs	https://doi.org/10.1016/j.parkreldis.2024.107117
Publication status	Published - Oct 2024

Keywords

Asymmetry
Imaging
Lewy body dementia
Lewy body disease
Parkinson's disease

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title = "Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study",

abstract = "INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.",

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author = "Jacob Horsager and Andersen, {Katrine B} and Niels Okkels and Karoline Knudsen and Casper Skj{\ae}rb{\ae}k and {Van Den Berge}, Nathalie and Nicola Pavese and Hanne Gottrup and Per Borghammer",

year = "2024",

month = oct,

doi = "10.1016/j.parkreldis.2024.107117",

language = "English",

volume = "127",

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Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study. / Horsager, Jacob ; Andersen, Katrine B ; Okkels, Niels et al.
In: Parkinsonism & Related Disorders, Vol. 127, 107117, 10.2024, p. 107117.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study

AU - Horsager, Jacob

AU - Andersen, Katrine B

AU - Okkels, Niels

AU - Knudsen, Karoline

AU - Skjærbæk, Casper

AU - Van Den Berge, Nathalie

AU - Pavese, Nicola

AU - Gottrup, Hanne

AU - Borghammer, Per

PY - 2024/10

Y1 - 2024/10

N2 - INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.

AB - INTRODUCTION: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric neuronal dysfunction and symptoms.METHODS: We included two patient groups: 19 non-demented Parkinson's disease (nPD) patients with [18F]FDG PET and motor symptoms assessed by UPDRS-III, and 65 Lewy body dementia (LBD) patients with [18F]FDG PET and dopamine radioisotope imaging. Asymmetry indices were calculated for [18F]FDG PET by including the cortex for each hemisphere, for dopamine radioisotope imaging by including the putamen and caudate separately, and for motor symptoms by using the difference between right-left UPDRS-III score. Correlations between these asymmetry indices were explored to test the predictions of the SOC model. To identify cases with a more typical LBD imaging profile, we calculated a Cingulate Island Sign (CIS) index on the [18F]FDG PET image.RESULTS: We found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and motor-symptom asymmetry in nPD patients (r = 0.62, P = 0.004). In patients with LBD, we found a significant correlation between cortical interhemispheric [18F]FDG asymmetry and dopamine transporter asymmetry in the caudate (r = 0.37, P = 0.0019), but not in the putamen (r = 0.15, P = 0.22). We observed that the correlation in the caudate was stronger in LBD subjects with the highest CIS index, i.e., with more typical LBD imaging profiles.CONCLUSION: Our study partly supports the SOC model, but further investigations are needed - ideally of de novo, non-demented PD patients.

KW - Asymmetry

KW - Imaging

KW - Lewy body dementia

KW - Lewy body disease

KW - Parkinson's disease

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U2 - 10.1016/j.parkreldis.2024.107117

DO - 10.1016/j.parkreldis.2024.107117

M3 - Journal article

C2 - 39217795

SN - 1353-8020

VL - 127

SP - 107117

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

M1 - 107117

ER -

Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study

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Keywords

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