Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment

Sofie Gottschalk Højfeldt, Kathrine Grell, Lone Hvitfeldt, Peder Skov Wehner, Jesper Bjerre, Birgitte Klug Albertsen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

Thromboembolism is a serious toxicity in the treatment of acute lymphoblastic leukemia (ALL), but little is known about the correlation between asparaginase enzyme activity (ASA) levels and coagulation parameters. We included 65 non-high risk ALL patients, aged 1-17 years. Coagulation parameters and corresponding ASA levels were measured during asparaginase treatment. We found ASA to be negatively correlated with antithrombin and fibrinogen up to ASA levels of 250 IU/L, after which these parameters reached a plateau and did not decrease further with further increase of ASA. Patients with silent inactivation of asparaginase had normal coagulation parameters.

Original languageEnglish
Article numbere30085
JournalPediatric Blood & Cancer
Volume70
Issue2
ISSN1545-5009
DOIs
Publication statusPublished - Feb 2023

Keywords

  • PEG-asparaginase
  • antithrombin
  • pediatric acute lymphoblastic leukemia
  • thromboembolism
  • toxicities

Fingerprint

Dive into the research topics of 'Correlation between asparaginase enzyme activity levels and coagulation parameters during childhood acute lymphoblastic leukemia treatment'. Together they form a unique fingerprint.

Cite this