Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study

Kristian L Funck; Ricardo P J Budde; Mette H Viuff; Jan Wen; Jesper M Jensen; Bjarne L Nørgaard; Lidia R Bons; Anthonie L Duijnhouwer; Damini Dey; Kristian H Mortensen; Niels H Andersen; Jolien W Roos-Hesselink; Claus H Gravholt

doi:10.1007/s00380-020-01660-7

Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study

Kristian L Funck, Ricardo P J Budde, Mette H Viuff, Jan Wen, Jesper M Jensen, Bjarne L Nørgaard, Lidia R Bons, Anthonie L Duijnhouwer, Damini Dey, Kristian H Mortensen, Niels H Andersen, Jolien W Roos-Hesselink, Claus H Gravholt

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were assessed for the presence and volume of subclinical CAD using coronary CT angiography. Karyotype, the presence of congenital heart defects and conventional cardiovascular risk factors were also registered. Comparative analyses were performed (1) between women with and without TS and (2) in the TS group, between women with and without subclinical CAD. The prevalence of CAD, in crude and adjusted analyses, was not increased for women with TS (crude prevalence: 40 [35%] in TS vs. 25 [47%] in controls, p = 0.12). The volume of atherosclerosis was not higher in women with TS compared with controls (median and interquartile range 0 [0-92] in TS vs. 0 [0-81]mm3 in controls, p = 0.29). Among women with TS, women with subclinical CAD were older (46 ± 13 vs. 37 ± 11 years, p < 0.001), had higher blood pressure (systolic blood pressure 129 ± 16 vs. 121 ± 16 mmHg, p < 0.05) and were more frequently diagnosed with type 2 diabetes (5 [13%] vs. 2 [3%], p < 0.05). Karyotype or congenital heart defects were not associated with subclinical CAD. Some women with TS show early signs of CAD, however overall, not more than women without TS. Conventional cardiovascular risk factors were the principal determinants of CAD also in TS, and CAD prevention strategies should be observed.ClinicalTrial.gov Identifier: NCT01678261 ( https://clinicaltrials.gov/ct2/show/NCT01678261 ).

Original language	English
Journal	Heart and Vessels
Volume	36
Issue	1
Pages (from-to)	14-23
Number of pages	10
ISSN	0910-8327
DOIs	https://doi.org/10.1007/s00380-020-01660-7
Publication status	Published - Jan 2021

Keywords

Abnormal karyotype
Anatomy
Atherosclerosis
Coronary artery disease
Embryology
Turner syndrome

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10.1007/s00380-020-01660-7

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Funck, K. L., Budde, R. P. J., Viuff, M. H., Wen, J., Jensen, J. M., Nørgaard, B. L., Bons, L. R., Duijnhouwer, A. L., Dey, D., Mortensen, K. H., Andersen, N. H., Roos-Hesselink, J. W., & Gravholt, C. H. (2021). Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study. Heart and Vessels, 36(1), 14-23. https://doi.org/10.1007/s00380-020-01660-7

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title = "Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study",

abstract = "Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were assessed for the presence and volume of subclinical CAD using coronary CT angiography. Karyotype, the presence of congenital heart defects and conventional cardiovascular risk factors were also registered. Comparative analyses were performed (1) between women with and without TS and (2) in the TS group, between women with and without subclinical CAD. The prevalence of CAD, in crude and adjusted analyses, was not increased for women with TS (crude prevalence: 40 [35%] in TS vs. 25 [47%] in controls, p = 0.12). The volume of atherosclerosis was not higher in women with TS compared with controls (median and interquartile range 0 [0-92] in TS vs. 0 [0-81]mm3 in controls, p = 0.29). Among women with TS, women with subclinical CAD were older (46 ± 13 vs. 37 ± 11 years, p < 0.001), had higher blood pressure (systolic blood pressure 129 ± 16 vs. 121 ± 16 mmHg, p < 0.05) and were more frequently diagnosed with type 2 diabetes (5 [13%] vs. 2 [3%], p < 0.05). Karyotype or congenital heart defects were not associated with subclinical CAD. Some women with TS show early signs of CAD, however overall, not more than women without TS. Conventional cardiovascular risk factors were the principal determinants of CAD also in TS, and CAD prevention strategies should be observed.ClinicalTrial.gov Identifier: NCT01678261 ( https://clinicaltrials.gov/ct2/show/NCT01678261 ).",

keywords = "Abnormal karyotype, Anatomy, Atherosclerosis, Coronary artery disease, Embryology, Turner syndrome",

author = "Funck, {Kristian L} and Budde, {Ricardo P J} and Viuff, {Mette H} and Jan Wen and Jensen, {Jesper M} and N{\o}rgaard, {Bjarne L} and Bons, {Lidia R} and Duijnhouwer, {Anthonie L} and Damini Dey and Mortensen, {Kristian H} and Andersen, {Niels H} and Roos-Hesselink, {Jolien W} and Gravholt, {Claus H}",

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T1 - Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study

AU - Funck, Kristian L

AU - Budde, Ricardo P J

AU - Viuff, Mette H

AU - Wen, Jan

AU - Jensen, Jesper M

AU - Nørgaard, Bjarne L

AU - Bons, Lidia R

AU - Duijnhouwer, Anthonie L

AU - Dey, Damini

AU - Mortensen, Kristian H

AU - Andersen, Niels H

AU - Roos-Hesselink, Jolien W

AU - Gravholt, Claus H

PY - 2021/1

Y1 - 2021/1

N2 - Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were assessed for the presence and volume of subclinical CAD using coronary CT angiography. Karyotype, the presence of congenital heart defects and conventional cardiovascular risk factors were also registered. Comparative analyses were performed (1) between women with and without TS and (2) in the TS group, between women with and without subclinical CAD. The prevalence of CAD, in crude and adjusted analyses, was not increased for women with TS (crude prevalence: 40 [35%] in TS vs. 25 [47%] in controls, p = 0.12). The volume of atherosclerosis was not higher in women with TS compared with controls (median and interquartile range 0 [0-92] in TS vs. 0 [0-81]mm3 in controls, p = 0.29). Among women with TS, women with subclinical CAD were older (46 ± 13 vs. 37 ± 11 years, p < 0.001), had higher blood pressure (systolic blood pressure 129 ± 16 vs. 121 ± 16 mmHg, p < 0.05) and were more frequently diagnosed with type 2 diabetes (5 [13%] vs. 2 [3%], p < 0.05). Karyotype or congenital heart defects were not associated with subclinical CAD. Some women with TS show early signs of CAD, however overall, not more than women without TS. Conventional cardiovascular risk factors were the principal determinants of CAD also in TS, and CAD prevention strategies should be observed.ClinicalTrial.gov Identifier: NCT01678261 ( https://clinicaltrials.gov/ct2/show/NCT01678261 ).

AB - Turner syndrome (TS) is associated with coronary artery disease (CAD), an important cause of premature death in TS. However, the determinants of CAD in women with TS remain unknown. In a cross-sectional study design, 168 women without clinical evidence of CAD (115 with TS and 53 without TS) were assessed for the presence and volume of subclinical CAD using coronary CT angiography. Karyotype, the presence of congenital heart defects and conventional cardiovascular risk factors were also registered. Comparative analyses were performed (1) between women with and without TS and (2) in the TS group, between women with and without subclinical CAD. The prevalence of CAD, in crude and adjusted analyses, was not increased for women with TS (crude prevalence: 40 [35%] in TS vs. 25 [47%] in controls, p = 0.12). The volume of atherosclerosis was not higher in women with TS compared with controls (median and interquartile range 0 [0-92] in TS vs. 0 [0-81]mm3 in controls, p = 0.29). Among women with TS, women with subclinical CAD were older (46 ± 13 vs. 37 ± 11 years, p < 0.001), had higher blood pressure (systolic blood pressure 129 ± 16 vs. 121 ± 16 mmHg, p < 0.05) and were more frequently diagnosed with type 2 diabetes (5 [13%] vs. 2 [3%], p < 0.05). Karyotype or congenital heart defects were not associated with subclinical CAD. Some women with TS show early signs of CAD, however overall, not more than women without TS. Conventional cardiovascular risk factors were the principal determinants of CAD also in TS, and CAD prevention strategies should be observed.ClinicalTrial.gov Identifier: NCT01678261 ( https://clinicaltrials.gov/ct2/show/NCT01678261 ).

KW - Abnormal karyotype

KW - Anatomy

KW - Atherosclerosis

KW - Coronary artery disease

KW - Embryology

KW - Turner syndrome

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U2 - 10.1007/s00380-020-01660-7

DO - 10.1007/s00380-020-01660-7

M3 - Journal article

C2 - 32613319

SN - 0910-8327

VL - 36

SP - 14

EP - 23

JO - Heart and Vessels

JF - Heart and Vessels

IS - 1

ER -

Coronary plaque burden in Turner syndrome a coronary computed tomography angiography study

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Keywords

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