Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark

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Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes : ADDITION-Denmark. / Andersen, Signe Toft; Grosen, Kasper; Tankisi, Hatice; Charles, Morten; Andersen, Niels T; Andersen, Henning; Petropoulos, Ioannis N; Malik, Rayaz A; Jensen, Troels S; Karlsson, Pall.

In: Journal of Diabetes and its Complications, Vol. 32, No. 12, 12.2018, p. 1153-1159.

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@article{587bdef591c249c881c0ea767ee719b0,
title = "Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes: ADDITION-Denmark",
abstract = "AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.",
keywords = "Corneal confocal microscopy, Diabetes, Diabetic complication, Diabetic polyneuropathy, Toronto consensus criteria",
author = "Andersen, {Signe Toft} and Kasper Grosen and Hatice Tankisi and Morten Charles and Andersen, {Niels T} and Henning Andersen and Petropoulos, {Ioannis N} and Malik, {Rayaz A} and Jensen, {Troels S} and Pall Karlsson",
note = "Copyright {\circledC} 2018 Elsevier Inc. All rights reserved.",
year = "2018",
month = "12",
doi = "10.1016/j.jdiacomp.2018.09.016",
language = "English",
volume = "32",
pages = "1153--1159",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier Inc",
number = "12",

}

RIS

TY - JOUR

T1 - Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes

T2 - ADDITION-Denmark

AU - Andersen, Signe Toft

AU - Grosen, Kasper

AU - Tankisi, Hatice

AU - Charles, Morten

AU - Andersen, Niels T

AU - Andersen, Henning

AU - Petropoulos, Ioannis N

AU - Malik, Rayaz A

AU - Jensen, Troels S

AU - Karlsson, Pall

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2018/12

Y1 - 2018/12

N2 - AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.

AB - AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.

KW - Corneal confocal microscopy

KW - Diabetes

KW - Diabetic complication

KW - Diabetic polyneuropathy

KW - Toronto consensus criteria

U2 - 10.1016/j.jdiacomp.2018.09.016

DO - 10.1016/j.jdiacomp.2018.09.016

M3 - Journal article

VL - 32

SP - 1153

EP - 1159

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 12

ER -