TY - JOUR
T1 - Corneal confocal microscopy as a tool for detecting diabetic polyneuropathy in a cohort with screen-detected type 2 diabetes
T2 - ADDITION-Denmark
AU - Andersen, Signe Toft
AU - Grosen, Kasper
AU - Tankisi, Hatice
AU - Charles, Morten
AU - Andersen, Niels T
AU - Andersen, Henning
AU - Petropoulos, Ioannis N
AU - Malik, Rayaz A
AU - Jensen, Troels S
AU - Karlsson, Pall
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2018/12
Y1 - 2018/12
N2 - AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.
AB - AIMS: In this cross-sectional study, we explored the utility of corneal confocal microscopy (CCM) measures for detecting diabetic polyneuropathy (DPN) and their association with clinical variables, in a cohort with type 2 diabetes.METHODS: CCM, nerve conduction studies, and assessment of symptoms and clinical deficits of DPN were undertaken in 144 participants with type 2 diabetes and 25 controls. DPN was defined according to the Toronto criteria for confirmed DPN.RESULTS: Corneal nerve fiber density (CNFD) was lower both in participants with confirmed DPN (n = 27) and in participants without confirmed DPN (n = 117) compared with controls (P = 0.04 and P = 0.01, respectively). No differences were observed for CNFD (P = 0.98) between participants with and without DPN. There were no differences in CNFL and CNBD between groups (P = 0.06 and P = 0.29, respectively). CNFD was associated with age, height, total- and LDL cholesterol.CONCLUSIONS: CCM could not distinguish patients with and without neuropathy, but CNFD was lower in patients with type 2 diabetes compared to controls. Age may influence the level of CCM measures.
KW - Corneal confocal microscopy
KW - Diabetes
KW - Diabetic complication
KW - Diabetic polyneuropathy
KW - Toronto consensus criteria
U2 - 10.1016/j.jdiacomp.2018.09.016
DO - 10.1016/j.jdiacomp.2018.09.016
M3 - Journal article
C2 - 30309785
SN - 1056-8727
VL - 32
SP - 1153
EP - 1159
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 12
ER -