Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members

Franziska Kriegenburg; Christian Ungermann; Fulvio Reggiori

doi:10.1016/j.cub.2018.02.034

Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members

Franziska Kriegenburg, Christian Ungermann, Fulvio Reggiori

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

76 Citations (Scopus)

Abstract

Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for lysosomal turnover. In a final step, autophagosomes fuse with lysosomes to release their cargo into the acidic and hydrolytic lumen of these organelles. In recent years, numerous new insights into this fusion event have been gained. Notably, many proteins implicated in autophagosome-lysosome fusion interact with members of the Atg8 protein family. Moreover, Atg8 proteins are described to have intrinsic membrane tethering and fusogenic properties themselves. Here, we summarize the current knowledge about the members of this intriguing protein family, which highlights them as possible hubs for the coordination of the final fusion stages of autophagy.

Original language	English
Journal	Current biology : CB
Volume	28
Issue	8
Pages (from-to)	R512-R518
ISSN	0960-9822
DOIs	https://doi.org/10.1016/j.cub.2018.02.034
Publication status	Published - 23 Apr 2018

Keywords

Animals
Autophagosomes/metabolism
Autophagy/physiology
Autophagy-Related Protein 8 Family/metabolism
Cytosol/metabolism
Humans
Lysosomes/metabolism
Membrane Fusion/physiology
Phagosomes/metabolism

Access to Document

10.1016/j.cub.2018.02.034

Cite this

@article{4596f8100774451a9e30d5b0fe2a1b18,

title = "Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members",

abstract = "Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for lysosomal turnover. In a final step, autophagosomes fuse with lysosomes to release their cargo into the acidic and hydrolytic lumen of these organelles. In recent years, numerous new insights into this fusion event have been gained. Notably, many proteins implicated in autophagosome-lysosome fusion interact with members of the Atg8 protein family. Moreover, Atg8 proteins are described to have intrinsic membrane tethering and fusogenic properties themselves. Here, we summarize the current knowledge about the members of this intriguing protein family, which highlights them as possible hubs for the coordination of the final fusion stages of autophagy.",

keywords = "Animals, Autophagosomes/metabolism, Autophagy/physiology, Autophagy-Related Protein 8 Family/metabolism, Cytosol/metabolism, Humans, Lysosomes/metabolism, Membrane Fusion/physiology, Phagosomes/metabolism",

author = "Franziska Kriegenburg and Christian Ungermann and Fulvio Reggiori",

year = "2018",

month = apr,

day = "23",

doi = "10.1016/j.cub.2018.02.034",

language = "English",

volume = "28",

pages = "R512--R518",

journal = "Current biology : CB",

issn = "0960-9822",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members

AU - Kriegenburg, Franziska

AU - Ungermann, Christian

AU - Reggiori, Fulvio

PY - 2018/4/23

Y1 - 2018/4/23

N2 - Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for lysosomal turnover. In a final step, autophagosomes fuse with lysosomes to release their cargo into the acidic and hydrolytic lumen of these organelles. In recent years, numerous new insights into this fusion event have been gained. Notably, many proteins implicated in autophagosome-lysosome fusion interact with members of the Atg8 protein family. Moreover, Atg8 proteins are described to have intrinsic membrane tethering and fusogenic properties themselves. Here, we summarize the current knowledge about the members of this intriguing protein family, which highlights them as possible hubs for the coordination of the final fusion stages of autophagy.

AB - Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for lysosomal turnover. In a final step, autophagosomes fuse with lysosomes to release their cargo into the acidic and hydrolytic lumen of these organelles. In recent years, numerous new insights into this fusion event have been gained. Notably, many proteins implicated in autophagosome-lysosome fusion interact with members of the Atg8 protein family. Moreover, Atg8 proteins are described to have intrinsic membrane tethering and fusogenic properties themselves. Here, we summarize the current knowledge about the members of this intriguing protein family, which highlights them as possible hubs for the coordination of the final fusion stages of autophagy.

KW - Animals

KW - Autophagosomes/metabolism

KW - Autophagy/physiology

KW - Autophagy-Related Protein 8 Family/metabolism

KW - Cytosol/metabolism

KW - Humans

KW - Lysosomes/metabolism

KW - Membrane Fusion/physiology

KW - Phagosomes/metabolism

U2 - 10.1016/j.cub.2018.02.034

DO - 10.1016/j.cub.2018.02.034

M3 - Review

C2 - 29689234

SN - 0960-9822

VL - 28

SP - R512-R518

JO - Current biology : CB

JF - Current biology : CB

IS - 8

ER -

Coordination of Autophagosome-Lysosome Fusion by Atg8 Family Members

Abstract

Keywords

Access to Document

Fingerprint

Cite this