Controlled chemical modification of biomolecules by femtosecond laser in polar liquids

Research output: Contribution to book/anthology/report/proceedingArticle in proceedingsResearchpeer-review

  • V. E. Gruzdev, University of Missouri-Columbia
  • ,
  • D. Korkin, Worcester Polytechnic Institute
  • ,
  • B. P. Mooney, University of Missouri-Columbia
  • ,
  • J. F. Havelund, Dept. of Biochemistry and Molecular Biology, University of Southern Denmark
  • ,
  • I. M. Møller
  • J. J. Thelen, University of Missouri-Columbia

Covalent chemical modification of peptides and human insulin by ultrashort laser pulses in room-temperature polar liquids show highly nonlinear scaling with laser intensity. Mass spectrometry analysis of the products obtained in acetonitrile-water and methanol-water, using isotope-marked liquids, and argon sparging demonstrates the participation of dissolved oxygen and interaction of the biomolecules with the laser-modified molecules derived from the liquids.

Original languageEnglish
Title of host publicationProceedings - International Conference Laser Optics 2018, ICLO 2018
Number of pages1
PublisherIEEE
Publication year13 Aug 2018
Article number8435786
ISBN (print)9781538636121
DOIs
Publication statusPublished - 13 Aug 2018
Event2018 International Conference Laser Optics, ICLO 2018 - St. Petersburg, Russian Federation
Duration: 4 Jun 20188 Jun 2018

Conference

Conference2018 International Conference Laser Optics, ICLO 2018
LandRussian Federation
BySt. Petersburg
Periode04/06/201808/06/2018

    Research areas

  • Biochemistry, Molecular biophysics, Peptide, Photochemistry, Protein engineering, Proteins

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