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Contrasting Connectivity of the Vim and Vop Nuclei of the Motor Thalamus Demonstrated by Probabilistic Tractography

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  • Jonathan A Hyam
  • ,
  • Sarah L F Owen
  • ,
  • Morten L. Kringelbach
  • Ned Jenkinson Phd
  • ,
  • John F Stein
  • ,
  • Alexander L Green
  • ,
  • Tipu Z Aziz
BACKGROUND:: Targeting of the motor thalamus for the treatment of tremor has traditionally been achieved by a combination of anatomical atlases and neuro-imaging, intra-operative clinical assessment, and physiological recordings. OBJECTIVE:: To evaluate whether thalamic nuclei targeted in tremor surgery could be identified by virtue of their differing connections using non-invasive neuro-imaging, thereby providing an extra factor to aid successful targeting. METHODS:: Diffusion tensor tractography was performed in seventeen healthy control subjects using diffusion data acquired at 1.5T magnetic resonance imaging (60 directions, b-value=1000 s/mm, 2x2x2 mm voxels). The ventralis intermedius (Vim) and ventralis oralis posterior (Vop) nuclei were identified by a stereotactic neurosurgeon and these sites were used as seeds for probabilistic tractography. The expected cortical connections of these nuclei were determined a priori from the literature, namely the primary motor cortex (M1) and contralateral cerebellum for the Vim and M1, the supplementary motor area (SMA) and dorsolateral prefrontal cortex (DLPFC) for the Vop. RESULTS:: Tractogram signal intensity was highest in the DLPFC and SMA after Vop seeding (p
Original languageEnglish
JournalTurkish Neurosurgery
ISSN1019-5149
DOIs
Publication statusPublished - 2011

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