Contractility patterns and gastrointestinal movements monitored by a combined magnetic tracking and motility testing unit

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DOI

  • Donghua Liao, Aalborg University
  • ,
  • Esben Bolvig Mark, Aalborg University
  • ,
  • Rasmus Bach Nedergaard, Aalborg University
  • ,
  • Anne Marie Wegeberg, Aalborg University
  • ,
  • Christina Brock, Aalborg University
  • ,
  • Klaus Krogh
  • Asbjørn Mohr Drewes, Aalborg University

Background: Ingestible wireless capsules, including the 3D-transit magnetic capsule and the wireless motility capsule (WMC), describe gastrointestinal (GI) motility from changes in position or pressure. This study aimed to combine information on contractile events in terms of position (assessed with the 3D-transit) and change in pressure (assessed with the WMC) throughout the entire GI tract. Methods: The 3D-transit capsule and WMC were combined into a single-wireless unit system. Three-dimensional space-time coordinates, pressure, and pH data from a pilot case were analyzed as the combined unit passed the GI tract. Two single and three continuous contraction patterns were defined according to pressure changes and quantified through the GI tract. Key results: The combined unit was well tolerated and provided information on contractions throughout the gut. Single contraction patterns with no significant progressive movement of the unit were most prevalent in the stomach and the rectosigmoid colon. During the continuous contraction patterns, the unit moved in an antegrade or retrograde direction. Longer distance and higher velocity were seen during antegrade than during retrograde movements. The motility indices (as measured with WMC) in combined ascending, transverse and descending colon showed a positive linear association (r = 0.7) to the capsule movements (as measured with 3D-transit). Conclusions & inferences: The combined system provides synchronous information about movements and gut contractions. These measurements can be used to extract more information from existing recordings and may enhance our understanding of GI motility in health and disease.

Original languageEnglish
Article numbere14306
JournalNeurogastroenterology and Motility
Volume34
Issue6
ISSN1350-1925
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Publisher Copyright:
© 2021 John Wiley & Sons Ltd.

    Research areas

  • contractility, gastrointestinal tract, ingestible wireless capsule, motility, synchronous

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