Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up

Christoffer Krogager; Anne Margareta Banghoj; Per L. Poulsen; Martin G. Kirkegaard; Birger Thorsteinsson; Lise Tarnow; Esben Laugesen; Klavs W. Hansen

doi:10.14740/jem773

Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up

Christoffer Krogager^*, Anne Margareta Banghoj, Per L. Poulsen, Martin G. Kirkegaard, Birger Thorsteinsson, Lise Tarnow, Esben Laugesen, Klavs W. Hansen

^*Corresponding author for this work

Department of Clinical Medicine - Department of Endocrinology and Internal Medicine
Department of Clinical Medicine - University Clinic for Interdisciplinary Orthopaedic Pathways (UCOP)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

41 Downloads (Pure)

Abstract

Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 ± 6.5 years, diabetes duration 16.1 ± 9.7 years, body mass index (BMI) 34.7 ± 3.9 kg/m²) partook in the study. Mean duration of CPAP treatment was 10.5 ± 1.5 months. Baseline cfPWV was 10.7 m/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV:-0.12 m/s, 95% confidence interval (CI):-0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 mm Hg, change in BP: 1.6 mm Hg, 95% CI:-2.3, 5.5. Conclusions: We found no effect of 9-12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.

Original language	English
Journal	Journal of Endocrinology and Metabolism
Volume	11
Issue	5
Pages (from-to)	134-139
Number of pages	6
ISSN	1923-2861
DOIs	https://doi.org/10.14740/jem773
Publication status	Published - Oct 2021

Keywords

Arterial stiffness
Diabetes
Obstructive sleep apnea
Pulse wave velocity

Access to Document

10.14740/jem773Licence: CC BY-NC

773-284286303-2-PBFinal published version, 332 KBLicence: CC BY-NC

Cite this

Krogager, C., Banghoj, A. M., Poulsen, P. L., Kirkegaard, M. G., Thorsteinsson, B., Tarnow, L., Laugesen, E., & Hansen, K. W. (2021). Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up. Journal of Endocrinology and Metabolism, 11(5), 134-139. https://doi.org/10.14740/jem773

@article{dffe966dc7e144c3b4a6e7be48a421f5,

title = "Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up",

abstract = "Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 ± 6.5 years, diabetes duration 16.1 ± 9.7 years, body mass index (BMI) 34.7 ± 3.9 kg/m2) partook in the study. Mean duration of CPAP treatment was 10.5 ± 1.5 months. Baseline cfPWV was 10.7 m/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV:-0.12 m/s, 95% confidence interval (CI):-0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 mm Hg, change in BP: 1.6 mm Hg, 95% CI:-2.3, 5.5. Conclusions: We found no effect of 9-12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.",

keywords = "Arterial stiffness, Diabetes, Obstructive sleep apnea, Pulse wave velocity",

author = "Christoffer Krogager and Banghoj, {Anne Margareta} and Poulsen, {Per L.} and Kirkegaard, {Martin G.} and Birger Thorsteinsson and Lise Tarnow and Esben Laugesen and Hansen, {Klavs W.}",

note = "Publisher Copyright: {\textcopyright} The authors | Journal compilation {\textcopyright} J Endocrinol Metab and Elmer Press Inc{\texttrademark} | www.jofem.org.",

year = "2021",

month = oct,

doi = "10.14740/jem773",

language = "English",

volume = "11",

pages = "134--139",

journal = "Journal of Endocrinology and Metabolism",

issn = "1923-2861",

publisher = "Elmer Press",

number = "5",

}

Krogager, C, Banghoj, AM, Poulsen, PL, Kirkegaard, MG, Thorsteinsson, B, Tarnow, L, Laugesen, E & Hansen, KW 2021, 'Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up', Journal of Endocrinology and Metabolism, vol. 11, no. 5, pp. 134-139. https://doi.org/10.14740/jem773

Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up. / Krogager, Christoffer; Banghoj, Anne Margareta; Poulsen, Per L. et al.
In: Journal of Endocrinology and Metabolism, Vol. 11, No. 5, 10.2021, p. 134-139.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up

AU - Krogager, Christoffer

AU - Banghoj, Anne Margareta

AU - Poulsen, Per L.

AU - Kirkegaard, Martin G.

AU - Thorsteinsson, Birger

AU - Tarnow, Lise

AU - Laugesen, Esben

AU - Hansen, Klavs W.

PY - 2021/10

Y1 - 2021/10

N2 - Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 ± 6.5 years, diabetes duration 16.1 ± 9.7 years, body mass index (BMI) 34.7 ± 3.9 kg/m2) partook in the study. Mean duration of CPAP treatment was 10.5 ± 1.5 months. Baseline cfPWV was 10.7 m/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV:-0.12 m/s, 95% confidence interval (CI):-0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 mm Hg, change in BP: 1.6 mm Hg, 95% CI:-2.3, 5.5. Conclusions: We found no effect of 9-12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.

AB - Background: The aim of this study is to evaluate the effects of 12-month continuous positive airway pressure (CPAP) treatment on arterial stiffness in patients with type 2 diabetes. Methods: Obstructive sleep apnea (OSA) and type 2 diabetes frequently co-exists. Both diseases increase arterial stiffness, a marker of cardiovascular risk. Treating OSA with CPAP may lower arterial stiffness. In a recent randomized trial, we found that CPAP treatment for 12 weeks did not reduce arterial stiffness in type 2 diabetes patients with OSA. Participants from the randomized trial were invited to a follow-up study 12 months after inclusion. We evaluated arterial stiffness by measuring carotid-femoral pulse wave velocity (cfPWV) using SphygmoCor. Results: Forty-six patients (63.9% of the original 72 patients, age 63.8 ± 6.5 years, diabetes duration 16.1 ± 9.7 years, body mass index (BMI) 34.7 ± 3.9 kg/m2) partook in the study. Mean duration of CPAP treatment was 10.5 ± 1.5 months. Baseline cfPWV was 10.7 m/s. At follow-up cfPWV was 10.6 m/s, change in cfPWV:-0.12 m/s, 95% confidence interval (CI):-0.6, 0.4, P = 0.6. Baseline systolic blood pressure (BP) was 136.2 mm Hg. At follow-up BP was 137.9 mm Hg, change in BP: 1.6 mm Hg, 95% CI:-2.3, 5.5. Conclusions: We found no effect of 9-12-month CPAP treatment on arterial stiffness or BP in patients with long duration of type 2 diabetes and OSA.

KW - Arterial stiffness

KW - Diabetes

KW - Obstructive sleep apnea

KW - Pulse wave velocity

UR - http://www.scopus.com/inward/record.url?scp=85118945500&partnerID=8YFLogxK

U2 - 10.14740/jem773

DO - 10.14740/jem773

M3 - Journal article

AN - SCOPUS:85118945500

SN - 1923-2861

VL - 11

SP - 134

EP - 139

JO - Journal of Endocrinology and Metabolism

JF - Journal of Endocrinology and Metabolism

IS - 5

ER -

Continuous positive airway pressure treatment for obstructive sleep apnea does not reduce arterial stiffness in patients with type 2 diabetes after one year of follow-up

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this