Contaminated dicloxacillin capsules as the source of an NDM-5/OXA-48-producing Enterobacter hormaechei ST79 outbreak, Denmark and Iceland, 2022 and 2023

Charlotte Nielsen Agergaard, Lone Jannok Porsbo, Thomas Vognbjerg Sydenham, Sanne Grønvall Kjær Hansen, Kat Steinke, Sanne Løkkegaard Larsen, Kristján Orri Helgason, Frank Hansen, Kasper Thystrup Karstensen, Anna E. Henius, Barbara Juliane Holzknecht, Lillian Søes, Kristian Schønning, Mikala Wang, Nina Ank, Anna Margrét Halldórsdóttir, Ólafur Guðlaugsson, Anette M. Hammerum, Anne Kjerulf, Brian KristensenHenrik Hasman, Ulrik Stenz Justesen*

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperLetterpeer-review

Abstract

From October 2022 through January 2023, nine patients with NDM-5/OXA-48-carbapenemase-producing Enterobacter hormaechei ST79 were detected in Denmark and subsequently one patient in Iceland. There were no nosocomial links between patients, but they had all been treated with dicloxacillin capsules. An NDM-5/OXA-48-carbapenemase-producing E. hormaechei ST79, identical to patient isolates, was cultured from the surface of dicloxacillin capsules in Denmark, strongly implicating them as the source of the outbreak. Special attention is required to detect the outbreak strain in the microbiology laboratory.

Original languageEnglish
JournalEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
Volume28
Issue9
Number of pages4
ISSN1025-496X
DOIs
Publication statusPublished - Mar 2023

Keywords

  • antibiotic
  • CPO
  • dicloxacillin
  • Enterobacter hormaechei
  • Outbreak

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