Construction of a 4 Zeptoliters Switchable 3D DNA Box Origami

Reza Mohammad Zadegan, Mette DE Jepsen, Karen E Thomsen, Anders Hauge Okholm, David Henning Schaffert, Ebbe Sloth Andersen, Victoria Birkedal, Jærgen Kjems

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review


The DNA origami technique is a recently developed self-assembly method that allows construction of 3D objects at the nanoscale for various applications. In the current study we report the production of a 18 × 18 × 24 nm3 hollow DNA box origami structure with a switchable lid. The structure was efficiently produced and characterized by atomic force microscopy, transmission electron microscopy, and Förster resonance energy transfer spectroscopy. The DNA box has a unique reclosing mechanism, which enables it to repeatedly open and close in response to a unique set of DNA keys. This DNA device can potentially be used for a broad range of applications such as controlling the function of single molecules, controlled drug delivery, and molecular computing
Original languageEnglish
JournalA C S Nano
Pages (from-to)10050-10053
Number of pages4
Publication statusPublished - 27 Nov 2012


  • 3D DNA origami
  • dynamic origami
  • multiswitchable nanostructure
  • FRET


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