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Constipation and risk of Parkinson's disease: A Danish population-based cohort study

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Constipation and risk of Parkinson's disease : A Danish population-based cohort study. / Svensson, Elisabeth; Henderson, Victor W; Borghammer, Per; Horváth-Puhó, Erzsébet; Sørensen, Henrik Toft.

In: Parkinsonism & Related Disorders, Vol. 28, 2016, p. 18-22.

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@article{f5a64a364f2a4c198b3592cadf4fc968,
title = "Constipation and risk of Parkinson's disease: A Danish population-based cohort study",
abstract = "OBJECTIVES: To examine long-term associations between constipation and Parkinson's disease (PD) in men and women, we conducted a population-based cohort study using prospectively collected registry data on hospital contacts for constipation and PD, stratified by follow-up time and sex.METHODS: We linked Danish registries to construct a cohort of all patients in Denmark with an outpatient hospital diagnosis of constipation 1995-2012 and a matched general population comparison cohort. Using Cox regression, we computed hazard ratios (HRs) for PD and corresponding 95{\%} confidence intervals (CIs), adjusting for potential confounders, stratified by sex and follow-up time.RESULTS: The 31,905 patients with constipation had a higher risk of PD than 159,092 comparison cohort members (adjusted (a) HR = 3.03, 95{\%} CI 2.50-3.66), which was sustained to 11-15 years follow-up (aHR = 3.65, 95{\%} CI 1.67-7.95). Increased risk was apparent in both sexes but stronger in men [aHR = 3.52 (2.67-4.64] than women [aHR = 2.64 (95{\%} CI 2.02-3.44].CONCLUSION: In this large population-based cohort study, constipation was associated with sustained increased risk of a PD diagnosis, and the relative risk was higher for men than for women.",
author = "Elisabeth Svensson and Henderson, {Victor W} and Per Borghammer and Erzs{\'e}bet Horv{\'a}th-Puh{\'o} and S{\o}rensen, {Henrik Toft}",
note = "Copyright {\circledC} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
doi = "10.1016/j.parkreldis.2016.05.016",
language = "English",
volume = "28",
pages = "18--22",
journal = "Parkinsonism & Related Disorders",
issn = "1353-8020",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Constipation and risk of Parkinson's disease

T2 - A Danish population-based cohort study

AU - Svensson, Elisabeth

AU - Henderson, Victor W

AU - Borghammer, Per

AU - Horváth-Puhó, Erzsébet

AU - Sørensen, Henrik Toft

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016

Y1 - 2016

N2 - OBJECTIVES: To examine long-term associations between constipation and Parkinson's disease (PD) in men and women, we conducted a population-based cohort study using prospectively collected registry data on hospital contacts for constipation and PD, stratified by follow-up time and sex.METHODS: We linked Danish registries to construct a cohort of all patients in Denmark with an outpatient hospital diagnosis of constipation 1995-2012 and a matched general population comparison cohort. Using Cox regression, we computed hazard ratios (HRs) for PD and corresponding 95% confidence intervals (CIs), adjusting for potential confounders, stratified by sex and follow-up time.RESULTS: The 31,905 patients with constipation had a higher risk of PD than 159,092 comparison cohort members (adjusted (a) HR = 3.03, 95% CI 2.50-3.66), which was sustained to 11-15 years follow-up (aHR = 3.65, 95% CI 1.67-7.95). Increased risk was apparent in both sexes but stronger in men [aHR = 3.52 (2.67-4.64] than women [aHR = 2.64 (95% CI 2.02-3.44].CONCLUSION: In this large population-based cohort study, constipation was associated with sustained increased risk of a PD diagnosis, and the relative risk was higher for men than for women.

AB - OBJECTIVES: To examine long-term associations between constipation and Parkinson's disease (PD) in men and women, we conducted a population-based cohort study using prospectively collected registry data on hospital contacts for constipation and PD, stratified by follow-up time and sex.METHODS: We linked Danish registries to construct a cohort of all patients in Denmark with an outpatient hospital diagnosis of constipation 1995-2012 and a matched general population comparison cohort. Using Cox regression, we computed hazard ratios (HRs) for PD and corresponding 95% confidence intervals (CIs), adjusting for potential confounders, stratified by sex and follow-up time.RESULTS: The 31,905 patients with constipation had a higher risk of PD than 159,092 comparison cohort members (adjusted (a) HR = 3.03, 95% CI 2.50-3.66), which was sustained to 11-15 years follow-up (aHR = 3.65, 95% CI 1.67-7.95). Increased risk was apparent in both sexes but stronger in men [aHR = 3.52 (2.67-4.64] than women [aHR = 2.64 (95% CI 2.02-3.44].CONCLUSION: In this large population-based cohort study, constipation was associated with sustained increased risk of a PD diagnosis, and the relative risk was higher for men than for women.

U2 - 10.1016/j.parkreldis.2016.05.016

DO - 10.1016/j.parkreldis.2016.05.016

M3 - Journal article

VL - 28

SP - 18

EP - 22

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

SN - 1353-8020

ER -