Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

  • Octavia Bane, BioMedical Engineering and Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
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  • Iosif A Mendichovszky, Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
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  • Bastien Milani, Center for BioMedical Imaging, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
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  • Ilona A Dekkers, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
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  • Jean-Francois Deux, Department of Radiology, Groupe Hospitalier Henri Mondor, Créteil, France.
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  • Per Eckerbom, Department of Radiology, Institution for Surgical Sciences, Uppsala University, Uppsala, Sweden.
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  • Nicolas Grenier, Department of Radiology, Université de Bordeaux, CHU de Bordeaux, Bordeaux, France.
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  • Michael E Hall, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
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  • Tsutomu Inoue, Department of Nephrology, Faculty of Medicine, Saitama Medical University, Saitama, Japan.
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  • Christoffer Laustsen
  • Lilach O Lerman, Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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  • Chunlei Liu, Electrical Engineering and Computer Science, and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
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  • Glen Morrell, Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, USA.
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  • Michael Pedersen
  • Menno Pruijm, Nephrology and Hypertension Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
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  • Elizabeth A Sadowski, Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
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  • Erdmann Seeliger, Institute of Physiology, Charité-University Medicine Berlin, Berlin, Germany.
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  • Kanishka Sharma, Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK. s.sourbron@leeds.ac.uk.
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  • Harriet Thoeny, Department of Radiology, Hôpital Cantonal Fribourgois (HFR), University of Fribourg, 1708, Fribourg, Switzerland.
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  • Peter Vermathen, Departments for BioMedical Research and Radiology, Inselspital, Universitaetspital Bern, Bern, Switzerland.
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  • Zhen J Wang, Department of Radiology and Biomedical Imaging, University of California San Francisco Medical Center, San Francisco, CA, USA.
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  • Zbigniew Serafin, Department of Radiology, Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, Poland.
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  • Jeff L Zhang, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
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  • Susan T Francis, Sir Peter Mansfield Centre, University of Notthingham, Notthingham, UK.
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  • Steven Sourbron, Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, UK. s.sourbron@leeds.ac.uk.
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  • Andreas Pohlmann, Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
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  • Sean B Fain, Departments of Biomedical Engineering, Radiology, and Medical Physics, University of Wisconsin, Madison, WI, USA.
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  • Pottumarthi V Prasad, Department of Radiology, Center for Advanced Imaging, NorthShore University Health System, Evanston, IL, USA. pprasad@northshore.org.

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Original languageEnglish
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume33
Issue1
Pages (from-to)199-215
Number of pages17
ISSN0968-5243
DOIs
Publication statusPublished - 2020

    Research areas

  • BOLD MRI, Biomarkers, Consensus, Imaging, Kidney, Standardization

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