Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

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Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. / Atasoy, Selen; Roseman, Leor; Kaelen, Mendel; Kringelbach, Morten L.; Deco, Gustavo; Carhart-Harris, Robin L.

In: Scientific Reports, Vol. 7, No. 1, 17661, 01.12.2017.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Atasoy, S, Roseman, L, Kaelen, M, Kringelbach, ML, Deco, G & Carhart-Harris, RL 2017, 'Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD', Scientific Reports, vol. 7, no. 1, 17661. https://doi.org/10.1038/s41598-017-17546-0

APA

Atasoy, S., Roseman, L., Kaelen, M., Kringelbach, M. L., Deco, G., & Carhart-Harris, R. L. (2017). Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. Scientific Reports, 7(1), [17661]. https://doi.org/10.1038/s41598-017-17546-0

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Atasoy, Selen ; Roseman, Leor ; Kaelen, Mendel ; Kringelbach, Morten L. ; Deco, Gustavo ; Carhart-Harris, Robin L. / Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD. In: Scientific Reports. 2017 ; Vol. 7, No. 1.

Bibtex

@article{b66d0f670b7842d688651a68077bd394,
title = "Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD",
abstract = "Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.",
author = "Selen Atasoy and Leor Roseman and Mendel Kaelen and Kringelbach, {Morten L.} and Gustavo Deco and Carhart-Harris, {Robin L.}",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-17546-0",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

AU - Atasoy, Selen

AU - Roseman, Leor

AU - Kaelen, Mendel

AU - Kringelbach, Morten L.

AU - Deco, Gustavo

AU - Carhart-Harris, Robin L.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

AB - Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

UR - http://www.scopus.com/inward/record.url?scp=85038263098&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-17546-0

DO - 10.1038/s41598-017-17546-0

M3 - Journal article

C2 - 29247209

AN - SCOPUS:85038263098

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 17661

ER -