Concomitant sarcoidosis and papillary thyroid cancer with severe hypercalcaemia as the main symptom

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  • Mikael Groth Riis, Randers Regional Hospital
  • ,
  • Kasper Svendsen Juhl, Randers Regional Hospital
  • ,
  • Jens Meldgaard Bruun

A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. A CT scan revealed an inhomogeneous thyroid gland and enlarged lymph nodes along the cervical vessels and in the mediastinum. The patient underwent total thyroidectomy and, at the same time, two lymph nodes were removed. Histological examination of the thyroid gland revealed papillary thyroid carcinoma (PTC), T1aN0M0, and histological examination of the lymph nodes showed non-caseating granulomatous inflammation. After further investigation, a diagnosis of sarcoidosis (SA) was made. Coexistence of SA and PTC may yield a diagnostic challenge as both diseases might involve the lymph nodes of the neck. Furthermore, the case illustrates the importance of close follow-up of even moderate hypercalcaemia, since it may evolve into a hypercalcaemic crisis.

Original languageEnglish
Article numberbcr-2017-222194
JournalBMJ Case Reports
Pages (from-to)2296-2305
Publication statusPublished - Jun 2018

    Research areas

  • endocrine cancer, immunology, thyroid disease

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