Department of Economics and Business Economics

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: The D-Tect study

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  • Amélie Keller, Copenhagen University Hospital, Copenhagen
  • ,
  • Mina N. Händel, Copenhagen University Hospital, Copenhagen
  • ,
  • Peder Frederiksen, Copenhagen University Hospital, Copenhagen
  • ,
  • Ramune Jacobsen, Copenhagen University Hospital, Copenhagen
  • ,
  • Arieh S. Cohen, Statens Serum Institut
  • ,
  • John J. McGrath
  • Berit L. Heitmann, Research Unit for Dietary Studies, Copenhagen University Hospital, Copenhagen, Boden Institute of Obesity, Sydney University, Sydney, Statens Institut for Folkesundhed, Københavns Universitet

Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002. There was an inverse association between 25(OH)D3 concentration and gestational age at birth of-0·006 (95 % CI-0·009,-0·003, P<0·001) weeks of gestation per 1 nmol/l increase in 25(OH)D3 concentration. An inverted U-shaped association between 25(OH)D3 and birth weight and Ponderal Index (P=0·04) was found, but no association with size for gestational age was shown. This study suggests that neonatal 25(OH)D3 concentration is associated with anthropometric measures at birth known to be correlated with many subsequent health outcomes such as obesity and type 2 diabetes.

Original languageEnglish
JournalBritish Journal of Nutrition
Volume119
Issue12
Pages (from-to)1416-1423
Number of pages8
ISSN0007-1145
DOIs
Publication statusPublished - 28 Jun 2018

    Research areas

  • Anthropometry, Dried blood spots, Neonatal outcomes, Vitamin D

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