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Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years

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Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years. / Andersen, Trine B; Erlandsen, Erland Jørn; Frøkiaer, Jørgen; Eskild-Jensen, Anni; Brøchner-Mortensen, Jens.

In: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 70, No. 1, 2010, p. 54-9.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Andersen, TB, Erlandsen, EJ, Frøkiaer, J, Eskild-Jensen, A & Brøchner-Mortensen, J 2010, 'Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 70, no. 1, pp. 54-9. https://doi.org/10.3109/00365510903556308

APA

Andersen, T. B., Erlandsen, E. J., Frøkiaer, J., Eskild-Jensen, A., & Brøchner-Mortensen, J. (2010). Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years. Scandinavian Journal of Clinical & Laboratory Investigation, 70(1), 54-9. https://doi.org/10.3109/00365510903556308

CBE

Andersen TB, Erlandsen EJ, Frøkiaer J, Eskild-Jensen A, Brøchner-Mortensen J. 2010. Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years. Scandinavian Journal of Clinical & Laboratory Investigation. 70(1):54-9. https://doi.org/10.3109/00365510903556308

MLA

Vancouver

Andersen TB, Erlandsen EJ, Frøkiaer J, Eskild-Jensen A, Brøchner-Mortensen J. Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years. Scandinavian Journal of Clinical & Laboratory Investigation. 2010;70(1):54-9. https://doi.org/10.3109/00365510903556308

Author

Andersen, Trine B ; Erlandsen, Erland Jørn ; Frøkiaer, Jørgen ; Eskild-Jensen, Anni ; Brøchner-Mortensen, Jens. / Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years. In: Scandinavian Journal of Clinical & Laboratory Investigation. 2010 ; Vol. 70, No. 1. pp. 54-9.

Bibtex

@article{dd3751e02dcd11df9806000ea68e967b,
title = "Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years",
abstract = "BACKGROUND: Previously, data on both the within-subject (SD(I)) and the between-subject (SD(G)) variation of cystatin C in children has not been reported. Thus, this study aimed to determine this biological variation including analytical variation (SD(A)) of both cystatin C and creatinine to characterize the two analytes as renal function markers in children. METHODS: On two consecutive days blood samples for duplicate analysis of cystatin C (nephelometric, Dade Behring) and creatinine (enzymatic, Roche) were obtained from 30 children (11 females and 19 males, mean age 8.3 range 2-13 years) referred for GFR measurements by (51)Cr-EDTA clearance. For determination of the between-subject variation only children with normal GFR (n=21) were included. Data were adjusted for the well known age-related increase in creatinine. RESULTS: The results are given as coefficients of variation. The within-subject variations were identical for both analytes (6.4%). The between-subject variation was 11.1% for cystatin C and 28.4% for creatinine, though decreasing to 20.1% after adjusting for age. The analytical variation was 1.7% and 2.5% for cystatin C and creatinine, respectively. The index of individuality (IOI = SD(I)/SD(G)) was 0.65 for cystatin C and 0.25 for creatinine, though increasing to 0.36 after age-adjustment. CONCLUSION: The within-subject variation was identical and low for cystatin C and creatinine suggesting that the two are equally suitable for serial monitoring of renal function in children. Based on the low IOI neither analyte, however, seems suitable as a screening marker of renal function in a healthy population of children using population-based reference intervals.",
author = "Andersen, {Trine B} and Erlandsen, {Erland J{\o}rn} and J{\o}rgen Fr{\o}kiaer and Anni Eskild-Jensen and Jens Br{\o}chner-Mortensen",
year = "2010",
doi = "10.3109/00365510903556308",
language = "English",
volume = "70",
pages = "54--9",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis ",
number = "1",

}

RIS

TY - JOUR

T1 - Comparison of within- and between-subject variation of serum cystatin C and serum creatinine in children aged 2-13 years

AU - Andersen, Trine B

AU - Erlandsen, Erland Jørn

AU - Frøkiaer, Jørgen

AU - Eskild-Jensen, Anni

AU - Brøchner-Mortensen, Jens

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Previously, data on both the within-subject (SD(I)) and the between-subject (SD(G)) variation of cystatin C in children has not been reported. Thus, this study aimed to determine this biological variation including analytical variation (SD(A)) of both cystatin C and creatinine to characterize the two analytes as renal function markers in children. METHODS: On two consecutive days blood samples for duplicate analysis of cystatin C (nephelometric, Dade Behring) and creatinine (enzymatic, Roche) were obtained from 30 children (11 females and 19 males, mean age 8.3 range 2-13 years) referred for GFR measurements by (51)Cr-EDTA clearance. For determination of the between-subject variation only children with normal GFR (n=21) were included. Data were adjusted for the well known age-related increase in creatinine. RESULTS: The results are given as coefficients of variation. The within-subject variations were identical for both analytes (6.4%). The between-subject variation was 11.1% for cystatin C and 28.4% for creatinine, though decreasing to 20.1% after adjusting for age. The analytical variation was 1.7% and 2.5% for cystatin C and creatinine, respectively. The index of individuality (IOI = SD(I)/SD(G)) was 0.65 for cystatin C and 0.25 for creatinine, though increasing to 0.36 after age-adjustment. CONCLUSION: The within-subject variation was identical and low for cystatin C and creatinine suggesting that the two are equally suitable for serial monitoring of renal function in children. Based on the low IOI neither analyte, however, seems suitable as a screening marker of renal function in a healthy population of children using population-based reference intervals.

AB - BACKGROUND: Previously, data on both the within-subject (SD(I)) and the between-subject (SD(G)) variation of cystatin C in children has not been reported. Thus, this study aimed to determine this biological variation including analytical variation (SD(A)) of both cystatin C and creatinine to characterize the two analytes as renal function markers in children. METHODS: On two consecutive days blood samples for duplicate analysis of cystatin C (nephelometric, Dade Behring) and creatinine (enzymatic, Roche) were obtained from 30 children (11 females and 19 males, mean age 8.3 range 2-13 years) referred for GFR measurements by (51)Cr-EDTA clearance. For determination of the between-subject variation only children with normal GFR (n=21) were included. Data were adjusted for the well known age-related increase in creatinine. RESULTS: The results are given as coefficients of variation. The within-subject variations were identical for both analytes (6.4%). The between-subject variation was 11.1% for cystatin C and 28.4% for creatinine, though decreasing to 20.1% after adjusting for age. The analytical variation was 1.7% and 2.5% for cystatin C and creatinine, respectively. The index of individuality (IOI = SD(I)/SD(G)) was 0.65 for cystatin C and 0.25 for creatinine, though increasing to 0.36 after age-adjustment. CONCLUSION: The within-subject variation was identical and low for cystatin C and creatinine suggesting that the two are equally suitable for serial monitoring of renal function in children. Based on the low IOI neither analyte, however, seems suitable as a screening marker of renal function in a healthy population of children using population-based reference intervals.

U2 - 10.3109/00365510903556308

DO - 10.3109/00365510903556308

M3 - Journal article

C2 - 20073673

VL - 70

SP - 54

EP - 59

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 1

ER -