TY - JOUR
T1 - Comparison of indirect treatment methods in migraine prevention to address differences in mode of administration
AU - Fawsitt, Christopher G.
AU - Thom, Howard
AU - Regnier, Stephane A.
AU - Lee, Xin Ying
AU - Kymes, Steven
AU - Vase, Lene
N1 - Publisher Copyright:
© 2023 The Authors.
PY - 2023/7
Y1 - 2023/7
N2 - Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route. Migraine preventive treatment studies were used to evaluate ITCs and determine whether mode of administration influences placebo response and the overall study findings. Materials & methods: Change from baseline in monthly migraine days produced by monoclonal antibody treatments (subcutaneous, intravenous) was compared using fixed-effects Bayesian network meta-analysis (NMA), network meta-regression (NMR), and unanchored simulated treatment comparison (STC). Results: NMA and NMR provide mixed, rarely differentiated results between treatments, whereas unanchored STC strongly favors eptinezumab over other preventive treatments. Conclusion: Further investigations are needed to determine which ITC best reflects the impact of mode of administration on placebo.
AB - Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route. Migraine preventive treatment studies were used to evaluate ITCs and determine whether mode of administration influences placebo response and the overall study findings. Materials & methods: Change from baseline in monthly migraine days produced by monoclonal antibody treatments (subcutaneous, intravenous) was compared using fixed-effects Bayesian network meta-analysis (NMA), network meta-regression (NMR), and unanchored simulated treatment comparison (STC). Results: NMA and NMR provide mixed, rarely differentiated results between treatments, whereas unanchored STC strongly favors eptinezumab over other preventive treatments. Conclusion: Further investigations are needed to determine which ITC best reflects the impact of mode of administration on placebo.
KW - indirect treatment comparisons
KW - intravenous
KW - migraine
KW - mode of administration
KW - network meta-analysis
KW - network meta-regression
KW - placebo response
KW - subcutaneous
KW - unanchored simulated treatment comparison
U2 - 10.57264/cer-2023-0021
DO - 10.57264/cer-2023-0021
M3 - Journal article
C2 - 37222593
AN - SCOPUS:85164160146
SN - 2042-6305
VL - 12
JO - Journal of Comparative Effectiveness Research
JF - Journal of Comparative Effectiveness Research
IS - 7
M1 - e230021
ER -