TY - JOUR
T1 - Comparison of admittance and cardiac magnetic resonance generated pressure-volume loops in a porcine model
AU - Andersen, Stine
AU - Laursen, Pernille Holmberg
AU - Wood, Gregory John
AU - Lyhne, Mads Dam
AU - Madsen, Tobias Lynge
AU - Hansen, Esben Søvsø Szocska
AU - Johansen, Peter
AU - Kim, Won Yong
AU - Andersen, Mads Jønsson
PY - 2024/5/1
Y1 - 2024/5/1
N2 - Objective. Pressure-volume loop analysis, traditionally performed by invasive pressure and volume measurements, is the optimal method for assessing ventricular function, while cardiac magnetic resonance (CMR) imaging is the gold standard for ventricular volume estimation. The aim of this study was to investigate the agreement between the assessment of end-systolic elastance (Ees) assessed with combined CMR and simultaneous pressure catheter measurements compared with admittance catheters in a porcine model. Approach. Seven healthy pigs underwent admittance-based pressure-volume loop evaluation followed by a second assessment with CMR during simultaneous pressure measurements. Main results. Admittance overestimated end-diastolic volume for both the left ventricle (LV) and the right ventricle (RV) compared with CMR. Further, there was an underestimation of RV end-systolic volume with admittance. For the RV, however, Ees was systematically higher when assessed with CMR plus simultaneous pressure measurements compared with admittance whereas there was no systematic difference in Ees but large differences between admittance and CMR-based methods for the LV. Significance. LV and RV Ees can be obtained from both admittance and CMR based techniques. There were discrepancies in volume estimates between admittance and CMR based methods, especially for the RV. RV Ees was higher when estimated by CMR with simultaneous pressure measurements compared with admittance.
AB - Objective. Pressure-volume loop analysis, traditionally performed by invasive pressure and volume measurements, is the optimal method for assessing ventricular function, while cardiac magnetic resonance (CMR) imaging is the gold standard for ventricular volume estimation. The aim of this study was to investigate the agreement between the assessment of end-systolic elastance (Ees) assessed with combined CMR and simultaneous pressure catheter measurements compared with admittance catheters in a porcine model. Approach. Seven healthy pigs underwent admittance-based pressure-volume loop evaluation followed by a second assessment with CMR during simultaneous pressure measurements. Main results. Admittance overestimated end-diastolic volume for both the left ventricle (LV) and the right ventricle (RV) compared with CMR. Further, there was an underestimation of RV end-systolic volume with admittance. For the RV, however, Ees was systematically higher when assessed with CMR plus simultaneous pressure measurements compared with admittance whereas there was no systematic difference in Ees but large differences between admittance and CMR-based methods for the LV. Significance. LV and RV Ees can be obtained from both admittance and CMR based techniques. There were discrepancies in volume estimates between admittance and CMR based methods, especially for the RV. RV Ees was higher when estimated by CMR with simultaneous pressure measurements compared with admittance.
KW - admittance
KW - cardiac function
KW - cardiac magnetic resonance imaging
KW - end-systolic elastance
KW - pressure-volume loops
KW - Magnetic Resonance Imaging
KW - Blood Pressure/physiology
KW - Animals
KW - Swine
KW - Models, Animal
KW - Heart Ventricles/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85194101924&partnerID=8YFLogxK
U2 - 10.1088/1361-6579/ad4a03
DO - 10.1088/1361-6579/ad4a03
M3 - Journal article
C2 - 38729184
SN - 0967-3334
VL - 45
JO - Physiological Measurement
JF - Physiological Measurement
IS - 5
M1 - 055014
ER -