Comparing the effect of strontium-functionalized and fluoride-modified surfaces on early osseointegration

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  • Vincent Offermanns, Med Univ Innsbruck, Medical University of Innsbruck, Dept Cranio Maxillofacial & Oral Surg
  • ,
  • Otto Steinmassl, Med Univ Innsbruck, Medical University of Innsbruck, Dept Cranio Maxillofacial & Oral Surg
  • ,
  • Ole Z. Andersen
  • ,
  • Christian S. Jeppesen, Danish Technol Inst, Tribol Ctr
  • ,
  • Soren Sorensen, Danish Technol Inst, Tribol Ctr
  • ,
  • Heribert Talasz, Med Univ Innsbruck, Medical University of Innsbruck, Div Clin Biochem, Bioctr
  • ,
  • Herbert H. Lindner, Med Univ Innsbruck, Medical University of Innsbruck, Div Clin Biochem, Bioctr
  • ,
  • Morten Foss
  • Frank Kloss

Background: Studies have shown that medical devices comprising strontium contribute to bone healing and osseointegration. The aim of this study was to evaluate the in vivo performance of surface-functionalized implants (Ti-Sr-O) showing predictable release characteristics of strontium and compare it to performance a commercially available fluoride-modified surface.

Methods: Ti-Sr-O functionalized, fluoride-modified, Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand white rabbits. Atomic absorption spectrometry (AAS) was utilized to monitor strontium blood serum levels. Two weeks after insertion, histomorphometric evaluation was performed with respect to bone-to-implant contact (BIC%) and bone formation (BF%) using defined regions of interest.

Results: Mean values for BIC% showed a comparable degree of osseointegration for Ti-Sr-O and the fluoride-modified surface, while BF% revealed a significant difference in increased BF with Ti-Sr-O. AAS measurements did not indicate any influence of the Ti-Sr-O modified implants on the strontium blood serum concentrations.

Conclusions: Within the limitations of this study, it was shown that the Ti-Sr-O coating, with sustained release characteristics of strontium, enhanced bone apposition and, thus, could find practical applications, e.g., within the field of medical implantology.

Original languageEnglish
JournalJournal of Periodontology
Volume89
Issue8
Pages (from-to)940-948
Number of pages9
ISSN0022-3492
DOIs
Publication statusPublished - Aug 2018

    Research areas

  • surface-crated materials, peri-implant endosseous healing, trace elements, bone, NZW rabbit, PARTIALLY EDENTULOUS PATIENTS, ACID-ETCHED SURFACE, TITANIUM IMPLANTS, DENTAL IMPLANTS, BONE, RANELATE, DOGS, OSTEOPOROSIS, INTEGRATION, DIFFERENTIATION

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