Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans

Peter Sieljacks; Line Thams; Birgitte Nellemann; Mads Sørensen Larsen; Kristian Vissing; Britt Christensen

doi:10.1519/JSC.0000000000001314

Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans

Peter Sieljacks, Line Thams, Birgitte Nellemann, Mads Sørensen Larsen, Kristian Vissing, Britt Christensen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

The present study examines responses to 10 weeks of aerobic training and/or erythropoiesis-stimulating agent (ESA) treatment on maximal oxygen uptake ((V) over dotO(2)max). Thirty-six healthy, untrained men were randomly assigned to sedentary-placebo (n = 9), sedentary-ESA (SE) (n = 9), training-placebo (TP) (n = 10), or training-ESA (TE) (n = 8). The participants were treated subcutaneously once weekly with ESA (darbepoietin-alpha, week 1-3; 40 mu g and week 4-10; 20 mu g) or a placebo for 10 weeks. The training consisted of supervised cycling 3 times per week for 1 hour at an average of 65% of maximal watt, with a progressive overload during the intervention period. (V) over dotO(2)max, wattmax, and hematological values were measured throughout the study. In addition, the total training workload and estimated energy consumption were recorded after each training session. ESA treatment increased hemoglobin (similar to 11 and similar to 14%, p <0.001) and hematocrit (similar to 12 and similar to 13%, p <0.001) in the SE and TE groups, respectively. The relative (but not absolute) increases in (V) over dotO(2)max were more pronounced (p <0.01) in TE (27 +/- 6%), compared with SE (15 +/- 4%) but not TP (19 +/- 4%), indicating that training is superior to ESA in stimulating (V) over dotO(2)max in untrained men. The increased oxygen uptake in the TE group did not result in higher absolute training workloads than in the TP group. In untrained men, training exhibits a greater stimulus for improvements in (V) over dotO(2)max than ESA treatment, without pronounced additive effects, which is supported by similar average training workloads and energy consumption in TP and TE. Thus, in untrained men, training alone seems sufficient to induce improvement in (V) over dotO(2)max.

Original language	English
Journal	Journal of Strength and Conditioning Research
Volume	30
Issue	8
Pages (from-to)	2307-2317
Number of pages	11
ISSN	1064-8011
DOIs	https://doi.org/10.1519/JSC.0000000000001314
Publication status	Published - Aug 2016

Keywords

Adult
Darbepoetin alfa
Erythropoietin
Exercise
Hematinics
Humans
Male
Oxygen Consumption
Young Adult
Comparative Study
Journal Article
Randomized Controlled Trial

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10.1519/JSC.0000000000001314

Cite this

@article{9b671b0665bf4e6fbfc9a23c50a8a32a,

title = "Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans",

abstract = "The present study examines responses to 10 weeks of aerobic training and/or erythropoiesis-stimulating agent (ESA) treatment on maximal oxygen uptake ((V) over dotO(2)max). Thirty-six healthy, untrained men were randomly assigned to sedentary-placebo (n = 9), sedentary-ESA (SE) (n = 9), training-placebo (TP) (n = 10), or training-ESA (TE) (n = 8). The participants were treated subcutaneously once weekly with ESA (darbepoietin-alpha, week 1-3; 40 mu g and week 4-10; 20 mu g) or a placebo for 10 weeks. The training consisted of supervised cycling 3 times per week for 1 hour at an average of 65% of maximal watt, with a progressive overload during the intervention period. (V) over dotO(2)max, wattmax, and hematological values were measured throughout the study. In addition, the total training workload and estimated energy consumption were recorded after each training session. ESA treatment increased hemoglobin (similar to 11 and similar to 14%, p <0.001) and hematocrit (similar to 12 and similar to 13%, p <0.001) in the SE and TE groups, respectively. The relative (but not absolute) increases in (V) over dotO(2)max were more pronounced (p <0.01) in TE (27 +/- 6%), compared with SE (15 +/- 4%) but not TP (19 +/- 4%), indicating that training is superior to ESA in stimulating (V) over dotO(2)max in untrained men. The increased oxygen uptake in the TE group did not result in higher absolute training workloads than in the TP group. In untrained men, training exhibits a greater stimulus for improvements in (V) over dotO(2)max than ESA treatment, without pronounced additive effects, which is supported by similar average training workloads and energy consumption in TP and TE. Thus, in untrained men, training alone seems sufficient to induce improvement in (V) over dotO(2)max.",

keywords = "Adult, Darbepoetin alfa, Erythropoietin, Exercise, Hematinics, Humans, Male, Oxygen Consumption, Young Adult, Comparative Study, Journal Article, Randomized Controlled Trial",

author = "Peter Sieljacks and Line Thams and Birgitte Nellemann and Larsen, {Mads S{\o}rensen} and Kristian Vissing and Britt Christensen",

year = "2016",

month = aug,

doi = "10.1519/JSC.0000000000001314",

language = "English",

volume = "30",

pages = "2307--2317",

journal = "Journal of Strength and Conditioning Research",

issn = "1064-8011",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "8",

}

Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans. / Sieljacks, Peter; Thams, Line; Nellemann, Birgitte et al.
In: Journal of Strength and Conditioning Research, Vol. 30, No. 8, 08.2016, p. 2307-2317.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans

AU - Sieljacks, Peter

AU - Thams, Line

AU - Nellemann, Birgitte

AU - Larsen, Mads Sørensen

AU - Vissing, Kristian

AU - Christensen, Britt

PY - 2016/8

Y1 - 2016/8

N2 - The present study examines responses to 10 weeks of aerobic training and/or erythropoiesis-stimulating agent (ESA) treatment on maximal oxygen uptake ((V) over dotO(2)max). Thirty-six healthy, untrained men were randomly assigned to sedentary-placebo (n = 9), sedentary-ESA (SE) (n = 9), training-placebo (TP) (n = 10), or training-ESA (TE) (n = 8). The participants were treated subcutaneously once weekly with ESA (darbepoietin-alpha, week 1-3; 40 mu g and week 4-10; 20 mu g) or a placebo for 10 weeks. The training consisted of supervised cycling 3 times per week for 1 hour at an average of 65% of maximal watt, with a progressive overload during the intervention period. (V) over dotO(2)max, wattmax, and hematological values were measured throughout the study. In addition, the total training workload and estimated energy consumption were recorded after each training session. ESA treatment increased hemoglobin (similar to 11 and similar to 14%, p <0.001) and hematocrit (similar to 12 and similar to 13%, p <0.001) in the SE and TE groups, respectively. The relative (but not absolute) increases in (V) over dotO(2)max were more pronounced (p <0.01) in TE (27 +/- 6%), compared with SE (15 +/- 4%) but not TP (19 +/- 4%), indicating that training is superior to ESA in stimulating (V) over dotO(2)max in untrained men. The increased oxygen uptake in the TE group did not result in higher absolute training workloads than in the TP group. In untrained men, training exhibits a greater stimulus for improvements in (V) over dotO(2)max than ESA treatment, without pronounced additive effects, which is supported by similar average training workloads and energy consumption in TP and TE. Thus, in untrained men, training alone seems sufficient to induce improvement in (V) over dotO(2)max.

AB - The present study examines responses to 10 weeks of aerobic training and/or erythropoiesis-stimulating agent (ESA) treatment on maximal oxygen uptake ((V) over dotO(2)max). Thirty-six healthy, untrained men were randomly assigned to sedentary-placebo (n = 9), sedentary-ESA (SE) (n = 9), training-placebo (TP) (n = 10), or training-ESA (TE) (n = 8). The participants were treated subcutaneously once weekly with ESA (darbepoietin-alpha, week 1-3; 40 mu g and week 4-10; 20 mu g) or a placebo for 10 weeks. The training consisted of supervised cycling 3 times per week for 1 hour at an average of 65% of maximal watt, with a progressive overload during the intervention period. (V) over dotO(2)max, wattmax, and hematological values were measured throughout the study. In addition, the total training workload and estimated energy consumption were recorded after each training session. ESA treatment increased hemoglobin (similar to 11 and similar to 14%, p <0.001) and hematocrit (similar to 12 and similar to 13%, p <0.001) in the SE and TE groups, respectively. The relative (but not absolute) increases in (V) over dotO(2)max were more pronounced (p <0.01) in TE (27 +/- 6%), compared with SE (15 +/- 4%) but not TP (19 +/- 4%), indicating that training is superior to ESA in stimulating (V) over dotO(2)max in untrained men. The increased oxygen uptake in the TE group did not result in higher absolute training workloads than in the TP group. In untrained men, training exhibits a greater stimulus for improvements in (V) over dotO(2)max than ESA treatment, without pronounced additive effects, which is supported by similar average training workloads and energy consumption in TP and TE. Thus, in untrained men, training alone seems sufficient to induce improvement in (V) over dotO(2)max.

KW - Adult

KW - Darbepoetin alfa

KW - Erythropoietin

KW - Exercise

KW - Hematinics

KW - Humans

KW - Male

KW - Oxygen Consumption

KW - Young Adult

KW - Comparative Study

KW - Journal Article

KW - Randomized Controlled Trial

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U2 - 10.1519/JSC.0000000000001314

DO - 10.1519/JSC.0000000000001314

M3 - Journal article

C2 - 26694499

SN - 1064-8011

VL - 30

SP - 2307

EP - 2317

JO - Journal of Strength and Conditioning Research

JF - Journal of Strength and Conditioning Research

IS - 8

ER -

Comparative Effects of Aerobic Training and Erythropoietin on Oxygen Uptake in Untrained Humans

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Keywords

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