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Comorbidity of schizophrenia and infection: a population-based cohort study

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Comorbidity of schizophrenia and infection : a population-based cohort study. / Nielsen, Philip Finn Rising; Laursen, Thomas Munk; Agerbo, Esben.

In: Social Psychiatry and Psychiatric Epidemiology, Vol. 51, No. 12, 2016, p. 1581-1589.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Nielsen, PFR, Laursen, TM & Agerbo, E 2016, 'Comorbidity of schizophrenia and infection: a population-based cohort study', Social Psychiatry and Psychiatric Epidemiology, vol. 51, no. 12, pp. 1581-1589. https://doi.org/10.1007/s00127-016-1297-1

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MLA

Nielsen, Philip Finn Rising, Thomas Munk Laursen, and Esben Agerbo. "Comorbidity of schizophrenia and infection: a population-based cohort study". Social Psychiatry and Psychiatric Epidemiology. 2016, 51(12). 1581-1589. https://doi.org/10.1007/s00127-016-1297-1

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Nielsen, Philip Finn Rising ; Laursen, Thomas Munk ; Agerbo, Esben. / Comorbidity of schizophrenia and infection : a population-based cohort study. In: Social Psychiatry and Psychiatric Epidemiology. 2016 ; Vol. 51, No. 12. pp. 1581-1589.

Bibtex

@article{f701d25ed517403e89eabcc1511aac86,
title = "Comorbidity of schizophrenia and infection: a population-based cohort study",
abstract = "PURPOSE: In this paper, we investigate the hypothesis that there is an overlap between infection and schizophrenia. Infections have been identified as a risk factor for schizophrenia, but the possible overlap between schizophrenia and infections remains unidentified so far. Here, we describe the use of the comorbidity index, a method for objectively integrating associations into a single measure estimating overlap.METHODS: Data were drawn from three population-based registers, the Civil Registration Register, the Danish Psychiatric Central Research Register, and the Danish National Hospital Register. We selected a cohort of 1,403,183 persons born in Denmark 1977-2002.RESULTS: Our results indicate that persons who have had a hospital contact with an infection (IRR 1.53, CI 1.46-1.61) are more likely to develop schizophrenia than persons who have not had such a contact. Persons who have had a diagnosis with schizophrenia are more likely to have had a hospital contact with an infection (IRR 1.73, 95 % CI 1.57-1.91) than persons who have had no schizophrenia diagnosis. A comorbidity index of 1.40 (95 % CI 1.34-1.46) was found, indicating an overlap between schizophrenia and infection.CONCLUSION: Our findings indicate that schizophrenia and infections overlap and that they share risk factors. The comorbidity index showed that the co-occurrence of schizophrenia and infection was 40 % higher than if the two disorders had occurred independently. Although the incidence of schizophrenia and infection was associated with each factor, the overlap could not be explained by urbanicity, parental history of psychiatric admission and infection.",
author = "Nielsen, {Philip Finn Rising} and Laursen, {Thomas Munk} and Esben Agerbo",
year = "2016",
doi = "10.1007/s00127-016-1297-1",
language = "English",
volume = "51",
pages = "1581--1589",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "Springer Medizin",
number = "12",

}

RIS

TY - JOUR

T1 - Comorbidity of schizophrenia and infection

T2 - a population-based cohort study

AU - Nielsen, Philip Finn Rising

AU - Laursen, Thomas Munk

AU - Agerbo, Esben

PY - 2016

Y1 - 2016

N2 - PURPOSE: In this paper, we investigate the hypothesis that there is an overlap between infection and schizophrenia. Infections have been identified as a risk factor for schizophrenia, but the possible overlap between schizophrenia and infections remains unidentified so far. Here, we describe the use of the comorbidity index, a method for objectively integrating associations into a single measure estimating overlap.METHODS: Data were drawn from three population-based registers, the Civil Registration Register, the Danish Psychiatric Central Research Register, and the Danish National Hospital Register. We selected a cohort of 1,403,183 persons born in Denmark 1977-2002.RESULTS: Our results indicate that persons who have had a hospital contact with an infection (IRR 1.53, CI 1.46-1.61) are more likely to develop schizophrenia than persons who have not had such a contact. Persons who have had a diagnosis with schizophrenia are more likely to have had a hospital contact with an infection (IRR 1.73, 95 % CI 1.57-1.91) than persons who have had no schizophrenia diagnosis. A comorbidity index of 1.40 (95 % CI 1.34-1.46) was found, indicating an overlap between schizophrenia and infection.CONCLUSION: Our findings indicate that schizophrenia and infections overlap and that they share risk factors. The comorbidity index showed that the co-occurrence of schizophrenia and infection was 40 % higher than if the two disorders had occurred independently. Although the incidence of schizophrenia and infection was associated with each factor, the overlap could not be explained by urbanicity, parental history of psychiatric admission and infection.

AB - PURPOSE: In this paper, we investigate the hypothesis that there is an overlap between infection and schizophrenia. Infections have been identified as a risk factor for schizophrenia, but the possible overlap between schizophrenia and infections remains unidentified so far. Here, we describe the use of the comorbidity index, a method for objectively integrating associations into a single measure estimating overlap.METHODS: Data were drawn from three population-based registers, the Civil Registration Register, the Danish Psychiatric Central Research Register, and the Danish National Hospital Register. We selected a cohort of 1,403,183 persons born in Denmark 1977-2002.RESULTS: Our results indicate that persons who have had a hospital contact with an infection (IRR 1.53, CI 1.46-1.61) are more likely to develop schizophrenia than persons who have not had such a contact. Persons who have had a diagnosis with schizophrenia are more likely to have had a hospital contact with an infection (IRR 1.73, 95 % CI 1.57-1.91) than persons who have had no schizophrenia diagnosis. A comorbidity index of 1.40 (95 % CI 1.34-1.46) was found, indicating an overlap between schizophrenia and infection.CONCLUSION: Our findings indicate that schizophrenia and infections overlap and that they share risk factors. The comorbidity index showed that the co-occurrence of schizophrenia and infection was 40 % higher than if the two disorders had occurred independently. Although the incidence of schizophrenia and infection was associated with each factor, the overlap could not be explained by urbanicity, parental history of psychiatric admission and infection.

U2 - 10.1007/s00127-016-1297-1

DO - 10.1007/s00127-016-1297-1

M3 - Journal article

C2 - 27761599

VL - 51

SP - 1581

EP - 1589

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

IS - 12

ER -