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Comorbidity in multiple sclerosis is associated with diagnostic delays and increased mortality

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  • Anja Thormann, Rigshosp, University of Copenhagen, Danish Multiple Sclerosis Registry, Dept Neurol
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  • Per Soelberg Sorensen, University of Copenhagen
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  • Nils Koch-Henriksen, Rigshosp, University of Copenhagen, Danish Multiple Sclerosis Registry, Dept Neurol
  • ,
  • Bjarne Laursen, Univ Southern Denmark, University of Southern Denmark, Danish Natl Inst Publ Hlth
  • ,
  • Melinda Magyari, Rigshosp, University of Copenhagen, Danish Multiple Sclerosis Registry, Dept Neurol

Objective:To investigate the effect of chronic comorbidity on the time of diagnosis of multiple sclerosis (MS) and on mortality in MS.Methods:We conducted a population-based, nationwide cohort study including all incident MS cases in Denmark with first MS symptom between 1980 and 2005. To investigate the time of diagnosis, we compared individuals with and without chronic comorbidity using multinomial logistic regression. To investigate mortality, we used Cox regression with time-dependent covariates, following study participants from clinical MS onset until endpoint (death) or to the end of the study, censuring at emigration.Results:We identified 8,947 individuals with clinical onset of MS between 1980 and 2005. In the study of time of diagnosis, we found statistically significant odds ratios for longer diagnostic delays with cerebrovascular comorbidity (2.01 [1.44-2.80];

Original languageEnglish
JournalNeurology
Volume89
Issue16
Pages (from-to)1668-1675
Number of pages8
ISSN0028-3878
DOIs
Publication statusPublished - 17 Oct 2017

    Research areas

  • REGISTRY, DENMARK, HEALTH, DISABILITY, NATIONWIDE, SURVIVAL, MS

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