Common neural signatures of psychedelics: Frequency-specific energy changes and repertoire expansion revealed using connectome-harmonic decomposition

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • Selen Atasoy, Aarhus Univ, Aarhus University, Ctr Mus Brain
  • ,
  • Jakub Vohryzek, Aarhus Univ, Aarhus University, Ctr Mus Brain
  • ,
  • Gustavo Deco, Monash Univ, Monash University, Sch Psychol Sci
  • ,
  • Robin L. Carhart-Harris, Imperial Coll London, Imperial College London, Div Brain Sci, Ctr Psychiat, Psychedel Res Grp
  • ,
  • Morten L. Kringelbach

The search for the universal laws of human brain function is still on-going but progress is being made. Here we describe the novel concepts of connectome harmonics and connectome-harmonic decomposition, which can be used to characterize the brain activity associated with any mental state. We use this new frequency-specific language to describe the brain activity elicited by psilocybin and LSD and find remarkably similar effects in terms of increases in total energy and power, as well as frequency-specific energy changes and repertoire expansion. In addition, we find enhanced signatures of criticality suggesting that the brain dynamics tune toward criticality in both psychedelic elicited states. Overall, our findings provide new evidence for the remarkable ability of psychedelics to change the spatiotemporal dynamics of the human brain.

Original languageEnglish
Title of host publicationPSYCHEDELIC NEUROSCIENCE
EditorsT Calvey
Number of pages24
PublisherElsevier
Publication year2018
Pages97-120
DOIs
Publication statusPublished - 2018
SeriesProgress in Brain Research
Volume242
ISSN0079-6123

    Research areas

  • Connectome harmonics, Brain, Psychedelics, Psilocybin, LSD, SELF-ORGANIZED CRITICALITY, FUNCTIONAL CONNECTIVITY, BRAIN ACTIVITY, INHIBITION, NETWORKS, SEGREGATION, INTEGRATION, UNDERLIES, WORKSPACE, CORTEX

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