Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.

Mogens Stender; Jens Brøndum Frøkjaer; Tina Sandie Hagedorn Nielsen; Torben Bjerregaard Larsen; Søren Lundbye-Christensen; Henrik Elbrønd; Ole Thorlacius-Ussing

doi:10.1160/TH07-06-0397

Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.

Mogens Stender, Jens Brøndum Frøkjaer, Tina Sandie Hagedorn Nielsen, Torben Bjerregaard Larsen, Søren Lundbye-Christensen, Henrik Elbrønd, Ole Thorlacius-Ussing

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low clinical pre-test probability (PTP) can be safely used to rule out the tentative diagnosis of DVT in cancer patients. However, the accuracy in colorectal cancer patients is uncertain. This study assessed the diagnostic accuracy of a quantitative D-dimer assay in combination with the PTP score in ruling out preoperative DVT in colorectal cancer patients admitted for surgery. Preoperative D-dimer test and compression ultrasonography for DVT were performed in 193 consecutive patients with newly diagnosed colorectal cancer. Diagnostic accuracy indices of the D-dimer test were assessed according to the PTP score. The negative predictive value, positive predictive value, sensitivity and specificity were 99% (95% confidence interval (CI), 95-100%), 17% (95% CI, 9-26), 93% (95% CI, 68-100%) and 61% (95% CI, 53-68%), respectively. In conclusion, the combined use of pre-test probability and D-dimer test may be useful in ruling out preoperative DVT in colorectal cancer patients admitted for surgery.

Original language	English
Journal	Thrombosis and Haemostasis
Volume	99
Issue	2
Pages (from-to)	396-400
Number of pages	4
ISSN	0340-6245
DOIs	https://doi.org/10.1160/TH07-06-0397
Publication status	Published - 2008

Keywords

Adult
Aged
Aged, 80 and over
Biological Markers
Colorectal Neoplasms
Female
Fibrin Fibrinogen Degradation Products
Humans
Male
Middle Aged
Predictive Value of Tests
Preoperative Care
Prospective Studies
ROC Curve
Reproducibility of Results
Risk Assessment
Risk Factors
Venous Thrombosis

Access to Document

10.1160/TH07-06-0397

Cite this

Stender, M., Frøkjaer, J. B., Hagedorn Nielsen, T. S., Larsen, T. B., Lundbye-Christensen, S., Elbrønd, H., & Thorlacius-Ussing, O. (2008). Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients. Thrombosis and Haemostasis, 99(2), 396-400. https://doi.org/10.1160/TH07-06-0397

@article{35fc4e00a66811dd889c000ea68e967b,

title = "Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.",

abstract = "The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low clinical pre-test probability (PTP) can be safely used to rule out the tentative diagnosis of DVT in cancer patients. However, the accuracy in colorectal cancer patients is uncertain. This study assessed the diagnostic accuracy of a quantitative D-dimer assay in combination with the PTP score in ruling out preoperative DVT in colorectal cancer patients admitted for surgery. Preoperative D-dimer test and compression ultrasonography for DVT were performed in 193 consecutive patients with newly diagnosed colorectal cancer. Diagnostic accuracy indices of the D-dimer test were assessed according to the PTP score. The negative predictive value, positive predictive value, sensitivity and specificity were 99% (95% confidence interval (CI), 95-100%), 17% (95% CI, 9-26), 93% (95% CI, 68-100%) and 61% (95% CI, 53-68%), respectively. In conclusion, the combined use of pre-test probability and D-dimer test may be useful in ruling out preoperative DVT in colorectal cancer patients admitted for surgery.",

keywords = "Adult, Aged, Aged, 80 and over, Biological Markers, Colorectal Neoplasms, Female, Fibrin Fibrinogen Degradation Products, Humans, Male, Middle Aged, Predictive Value of Tests, Preoperative Care, Prospective Studies, ROC Curve, Reproducibility of Results, Risk Assessment, Risk Factors, Venous Thrombosis",

author = "Mogens Stender and Fr{\o}kjaer, {Jens Br{\o}ndum} and {Hagedorn Nielsen}, {Tina Sandie} and Larsen, {Torben Bjerregaard} and S{\o}ren Lundbye-Christensen and Henrik Elbr{\o}nd and Ole Thorlacius-Ussing",

year = "2008",

doi = "10.1160/TH07-06-0397",

language = "English",

volume = "99",

pages = "396--400",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Schattauer",

number = "2",

}

Stender, M, Frøkjaer, JB, Hagedorn Nielsen, TS, Larsen, TB, Lundbye-Christensen, S, Elbrønd, H & Thorlacius-Ussing, O 2008, 'Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.', Thrombosis and Haemostasis, vol. 99, no. 2, pp. 396-400. https://doi.org/10.1160/TH07-06-0397

Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients. / Stender, Mogens; Frøkjaer, Jens Brøndum; Hagedorn Nielsen, Tina Sandie et al.
In: Thrombosis and Haemostasis, Vol. 99, No. 2, 2008, p. 396-400.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.

AU - Stender, Mogens

AU - Frøkjaer, Jens Brøndum

AU - Hagedorn Nielsen, Tina Sandie

AU - Larsen, Torben Bjerregaard

AU - Lundbye-Christensen, Søren

AU - Elbrønd, Henrik

AU - Thorlacius-Ussing, Ole

PY - 2008

Y1 - 2008

N2 - The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low clinical pre-test probability (PTP) can be safely used to rule out the tentative diagnosis of DVT in cancer patients. However, the accuracy in colorectal cancer patients is uncertain. This study assessed the diagnostic accuracy of a quantitative D-dimer assay in combination with the PTP score in ruling out preoperative DVT in colorectal cancer patients admitted for surgery. Preoperative D-dimer test and compression ultrasonography for DVT were performed in 193 consecutive patients with newly diagnosed colorectal cancer. Diagnostic accuracy indices of the D-dimer test were assessed according to the PTP score. The negative predictive value, positive predictive value, sensitivity and specificity were 99% (95% confidence interval (CI), 95-100%), 17% (95% CI, 9-26), 93% (95% CI, 68-100%) and 61% (95% CI, 53-68%), respectively. In conclusion, the combined use of pre-test probability and D-dimer test may be useful in ruling out preoperative DVT in colorectal cancer patients admitted for surgery.

AB - The preoperative prevalence of deep venous thrombosis (DVT) in patients with colorectal cancer may be as high as 8%. In order to minimize the risk of pulmonary embolism, it is important to rule out preoperative DVT. A large study has confirmed that a negative D-dimer test in combination with a low clinical pre-test probability (PTP) can be safely used to rule out the tentative diagnosis of DVT in cancer patients. However, the accuracy in colorectal cancer patients is uncertain. This study assessed the diagnostic accuracy of a quantitative D-dimer assay in combination with the PTP score in ruling out preoperative DVT in colorectal cancer patients admitted for surgery. Preoperative D-dimer test and compression ultrasonography for DVT were performed in 193 consecutive patients with newly diagnosed colorectal cancer. Diagnostic accuracy indices of the D-dimer test were assessed according to the PTP score. The negative predictive value, positive predictive value, sensitivity and specificity were 99% (95% confidence interval (CI), 95-100%), 17% (95% CI, 9-26), 93% (95% CI, 68-100%) and 61% (95% CI, 53-68%), respectively. In conclusion, the combined use of pre-test probability and D-dimer test may be useful in ruling out preoperative DVT in colorectal cancer patients admitted for surgery.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biological Markers

KW - Colorectal Neoplasms

KW - Female

KW - Fibrin Fibrinogen Degradation Products

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Preoperative Care

KW - Prospective Studies

KW - ROC Curve

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Venous Thrombosis

U2 - 10.1160/TH07-06-0397

DO - 10.1160/TH07-06-0397

M3 - Journal article

C2 - 18278191

SN - 0340-6245

VL - 99

SP - 396

EP - 400

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

IS - 2

ER -

Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients.

Abstract

Keywords

Access to Document

Fingerprint

Cite this