Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

Yacoub Y I Amin, Kasper Runager, Fabio Simoes, Adam Celiz, Vincenzo Taresco, Roberto Rossi, Jan J Enghild, Lisbeth A Abildtrup, David C E Kraft, Duncan S Sutherland, Morgan R Alexander, Morten Foss, Ryosuke Ogaki

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Abstract

A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.

Original languageEnglish
JournalAdvanced Materials
ISSN0935-9648
DOIs
Publication statusPublished - 9 Dec 2015

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