Colonic volume in patients with functional constipation or irritable bowel syndrome determined by magnetic resonance imaging

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DOI

  • Mette Winther Klinge
  • Klaus Krogh
  • Esben Bolvig Mark, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Asbjørn Mohr Drewes
  • Lau Brix
  • Christin Isaksen, Diagnostic Centre, Orthopedic Department, Regional Hospital Silkeborg, Silkeborg, Denmark.
  • ,
  • Milda Dedelaite, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Jens Brøndum Frøkjaer, Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Moelleparkvej 4, 9000 Aalborg, Denmark ; Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark.
  • ,
  • Lotte Vinskov Fynne

BACKGROUND: Functional constipation (FC) and irritable bowel syndrome constipation type (IBS-C) share many similarities, and it remains unknown whether they are distinct entities or part of the same spectrum of disease. Magnetic resonance imaging (MRI) allows quantification of intraluminal fecal volume. We hypothesized that colonic volumes of patients with FC would be larger than those of patients with IBS-C, and that both patient groups would have larger colonic volumes than healthy controls (HC).

METHODS: Based on validated questionnaires, three groups of participants were classified into FC (n = 13), IBS-C (n = 10), and HC (n = 19). The colonic volume of each subject was determined by MRI. Stool consistency was described by the Bristol stool scale and colonic transit times were assessed with radiopaque makers.

KEY RESULTS: Overall, total colonic volumes were different in the three groups, HC (median 629 ml, interquartile range (IQR)(562-868)), FC (864 ml, IQR(742-940)), and IBS-C (520 ml IQR(489-593)) (p = 0.001). Patients with IBS-C had lower colonic volumes than patients with FC (p = 0.001) and HC (p = 0.019), but there was no difference between FC and HC (p = 0.10). Stool consistency was similar in the two patient groups, but patients with FC had longer colonic transit time than those with IBS-C (117.6 h versus 43.2 h, p = 0.019).

CONCLUSION: Patients with IBS-C have lower total colonic volumes and shorter colonic transit times than patients with FC. Future studies are needed to confirm that colonic volume allows objective distinction between the two conditions.

Original languageEnglish
JournalNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Pages (from-to)e14374
ISSN1365-2982
DOIs
Publication statusE-pub ahead of print - 5 Apr 2022

Bibliographical note

© 2022 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.

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