Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients

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Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients. / Bennedsgaard, Kristine ; Ventzel, Lise; Grafe, Peter; Tigerholm, Jenny; Themistocleous, Andreas C.; Bennett, David L.; Tankisi, Hatice ; Finnerup, Nanna B.

In: Muscle and Nerve, Vol. 61, No. 6, 2020, p. 796-800.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Bibtex

@article{0ab1b662b9264a34b2082b7595b6ef5f,

title = "Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients",

abstract = "Introduction: Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Methods: Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baseline and after the second or third oxaliplatin cycle at different skin temperatures. Results: Seven patients were eligible for examination. All patients felt evoked pain and tingling when touching something cold after oxaliplatin infusion. Oxaliplatin decreased motor nerve superexcitability (P <.001), increased relative refractory period (P =.011), and caused neuromyotonia-like after-activity. Cooling exacerbated these changes and prolonged the accommodation half-time. Discussion: The findings suggest that a combined effect of oxaliplatin and cooling facilitates nerve excitability changes and neuromyotonia-like after-activity in peripheral nerve axons. A possible mechanism is the slowing in gating of voltage-dependent fast sodium and slow potassium channels, which results in symptoms of cold allodynia.",

keywords = "allodynia, nerve excitability testing, neuropathy, oxaliplatin toxicity, potassium channel dysfunction, sodium channel dysfunction",

author = "Kristine Bennedsgaard and Lise Ventzel and Peter Grafe and Jenny Tigerholm and Themistocleous, {Andreas C.} and Bennett, {David L.} and Hatice Tankisi and Finnerup, {Nanna B.}",

year = "2020",

doi = "10.1002/mus.26852",

language = "English",

volume = "61",

pages = "796--800",

journal = "Muscle & Nerve",

issn = "0148-639X",

publisher = "JohnWiley & Sons, Inc.",

number = "6",

}

RIS

TY - JOUR

T1 - Cold aggravates abnormal excitability of motor axons in oxaliplatin-treated patients

AU - Bennedsgaard, Kristine

AU - Ventzel, Lise

AU - Grafe, Peter

AU - Tigerholm, Jenny

AU - Themistocleous, Andreas C.

AU - Bennett, David L.

AU - Tankisi, Hatice

AU - Finnerup, Nanna B.

PY - 2020

Y1 - 2020

N2 - Introduction: Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Methods: Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baseline and after the second or third oxaliplatin cycle at different skin temperatures. Results: Seven patients were eligible for examination. All patients felt evoked pain and tingling when touching something cold after oxaliplatin infusion. Oxaliplatin decreased motor nerve superexcitability (P <.001), increased relative refractory period (P =.011), and caused neuromyotonia-like after-activity. Cooling exacerbated these changes and prolonged the accommodation half-time. Discussion: The findings suggest that a combined effect of oxaliplatin and cooling facilitates nerve excitability changes and neuromyotonia-like after-activity in peripheral nerve axons. A possible mechanism is the slowing in gating of voltage-dependent fast sodium and slow potassium channels, which results in symptoms of cold allodynia.

AB - Introduction: Cold allodynia is often seen in the acute phase of oxaliplatin treatment, but the underlying pathophysiology remains unclear. Methods: Patients scheduled for adjuvant oxaliplatin for colorectal cancer were examined with quantitative sensory testing and nerve excitability tests at baseline and after the second or third oxaliplatin cycle at different skin temperatures. Results: Seven patients were eligible for examination. All patients felt evoked pain and tingling when touching something cold after oxaliplatin infusion. Oxaliplatin decreased motor nerve superexcitability (P <.001), increased relative refractory period (P =.011), and caused neuromyotonia-like after-activity. Cooling exacerbated these changes and prolonged the accommodation half-time. Discussion: The findings suggest that a combined effect of oxaliplatin and cooling facilitates nerve excitability changes and neuromyotonia-like after-activity in peripheral nerve axons. A possible mechanism is the slowing in gating of voltage-dependent fast sodium and slow potassium channels, which results in symptoms of cold allodynia.

KW - allodynia

KW - nerve excitability testing

KW - neuropathy

KW - oxaliplatin toxicity

KW - potassium channel dysfunction

KW - sodium channel dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85082667812&partnerID=8YFLogxK

U2 - 10.1002/mus.26852

DO - 10.1002/mus.26852

M3 - Journal article

C2 - 32133655

AN - SCOPUS:85082667812

VL - 61

SP - 796

EP - 800

JO - Muscle & Nerve

JF - Muscle & Nerve

SN - 0148-639X

IS - 6

ER -