Department of Economics and Business Economics

Cohort profile: the Australian genetics of depression study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Cohort profile : the Australian genetics of depression study. / Byrne, Enda M; Kirk, Katherine M; Medland, Sarah E; McGrath, John J; Colodro-Conde, Lucia; Parker, Richard; Cross, Simone; Sullivan, Lenore; Statham, Dixie J; Levinson, Douglas F; Licinio, Julio; Wray, Naomi R; Hickie, Ian B; Martin, Nicholas G.

In: BMJ Open, Vol. 10, No. 5, e032580, 05.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Byrne, EM, Kirk, KM, Medland, SE, McGrath, JJ, Colodro-Conde, L, Parker, R, Cross, S, Sullivan, L, Statham, DJ, Levinson, DF, Licinio, J, Wray, NR, Hickie, IB & Martin, NG 2020, 'Cohort profile: the Australian genetics of depression study', BMJ Open, vol. 10, no. 5, e032580. https://doi.org/10.1136/bmjopen-2019-032580

APA

Byrne, E. M., Kirk, K. M., Medland, S. E., McGrath, J. J., Colodro-Conde, L., Parker, R., Cross, S., Sullivan, L., Statham, D. J., Levinson, D. F., Licinio, J., Wray, N. R., Hickie, I. B., & Martin, N. G. (2020). Cohort profile: the Australian genetics of depression study. BMJ Open, 10(5), [e032580]. https://doi.org/10.1136/bmjopen-2019-032580

CBE

Byrne EM, Kirk KM, Medland SE, McGrath JJ, Colodro-Conde L, Parker R, Cross S, Sullivan L, Statham DJ, Levinson DF, Licinio J, Wray NR, Hickie IB, Martin NG. 2020. Cohort profile: the Australian genetics of depression study. BMJ Open. 10(5):Article e032580. https://doi.org/10.1136/bmjopen-2019-032580

MLA

Vancouver

Byrne EM, Kirk KM, Medland SE, McGrath JJ, Colodro-Conde L, Parker R et al. Cohort profile: the Australian genetics of depression study. BMJ Open. 2020 May;10(5). e032580. https://doi.org/10.1136/bmjopen-2019-032580

Author

Byrne, Enda M ; Kirk, Katherine M ; Medland, Sarah E ; McGrath, John J ; Colodro-Conde, Lucia ; Parker, Richard ; Cross, Simone ; Sullivan, Lenore ; Statham, Dixie J ; Levinson, Douglas F ; Licinio, Julio ; Wray, Naomi R ; Hickie, Ian B ; Martin, Nicholas G. / Cohort profile : the Australian genetics of depression study. In: BMJ Open. 2020 ; Vol. 10, No. 5.

Bibtex

@article{f2101569e100469a935feb8ba28ef562,
title = "Cohort profile: the Australian genetics of depression study",
abstract = "PURPOSE: Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants.PARTICIPANTS: A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail.FINDINGS TO DATE: 95% of participants reported being given a diagnosis of depression by a medical practitioner and 88% met the criteria for a lifetime depressive episode. 68% of the sample report having been diagnosed with another psychiatric disorder in addition to depression. In line with findings from clinical trials, only 33% of the sample report responding well to the first antidepressant they were prescribed.FUTURE PLANS: A number of analyses to investigate the genetic architecture of depression and common comorbidities will be conducted. The cohort will contribute to the global effort to identify genetic variants that increase risk to depression. Furthermore, a thorough investigation of genetic and psychosocial predictors of antidepressant response and side effects is planned.",
author = "Byrne, {Enda M} and Kirk, {Katherine M} and Medland, {Sarah E} and McGrath, {John J} and Lucia Colodro-Conde and Richard Parker and Simone Cross and Lenore Sullivan and Statham, {Dixie J} and Levinson, {Douglas F} and Julio Licinio and Wray, {Naomi R} and Hickie, {Ian B} and Martin, {Nicholas G}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2020",
month = may,
doi = "10.1136/bmjopen-2019-032580",
language = "English",
volume = "10",
journal = "B M J Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Cohort profile

T2 - the Australian genetics of depression study

AU - Byrne, Enda M

AU - Kirk, Katherine M

AU - Medland, Sarah E

AU - McGrath, John J

AU - Colodro-Conde, Lucia

AU - Parker, Richard

AU - Cross, Simone

AU - Sullivan, Lenore

AU - Statham, Dixie J

AU - Levinson, Douglas F

AU - Licinio, Julio

AU - Wray, Naomi R

AU - Hickie, Ian B

AU - Martin, Nicholas G

N1 - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020/5

Y1 - 2020/5

N2 - PURPOSE: Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants.PARTICIPANTS: A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail.FINDINGS TO DATE: 95% of participants reported being given a diagnosis of depression by a medical practitioner and 88% met the criteria for a lifetime depressive episode. 68% of the sample report having been diagnosed with another psychiatric disorder in addition to depression. In line with findings from clinical trials, only 33% of the sample report responding well to the first antidepressant they were prescribed.FUTURE PLANS: A number of analyses to investigate the genetic architecture of depression and common comorbidities will be conducted. The cohort will contribute to the global effort to identify genetic variants that increase risk to depression. Furthermore, a thorough investigation of genetic and psychosocial predictors of antidepressant response and side effects is planned.

AB - PURPOSE: Depression is the most common psychiatric disorder and the largest contributor to global disability. The Australian Genetics of Depression study was established to recruit a large cohort of individuals who have been diagnosed with depression at some point in their lifetime. The purpose of establishing this cohort is to investigate genetic and environmental risk factors for depression and response to commonly prescribed antidepressants.PARTICIPANTS: A total of 20 689 participants were recruited through the Australian Department of Human Services and a media campaign, 75% of whom were female. The average age of participants was 43 years±15 years. Participants completed an online questionnaire that consisted of a compulsory module that assessed self-reported psychiatric history, clinical depression using the Composite Interview Diagnostic Interview Short Form and experiences of using commonly prescribed antidepressants. Further voluntary modules assessed a wide range of traits of relevance to psychopathology. Participants who reported they were willing to provide a DNA sample (75%) were sent a saliva kit in the mail.FINDINGS TO DATE: 95% of participants reported being given a diagnosis of depression by a medical practitioner and 88% met the criteria for a lifetime depressive episode. 68% of the sample report having been diagnosed with another psychiatric disorder in addition to depression. In line with findings from clinical trials, only 33% of the sample report responding well to the first antidepressant they were prescribed.FUTURE PLANS: A number of analyses to investigate the genetic architecture of depression and common comorbidities will be conducted. The cohort will contribute to the global effort to identify genetic variants that increase risk to depression. Furthermore, a thorough investigation of genetic and psychosocial predictors of antidepressant response and side effects is planned.

U2 - 10.1136/bmjopen-2019-032580

DO - 10.1136/bmjopen-2019-032580

M3 - Journal article

C2 - 32461290

VL - 10

JO - B M J Open

JF - B M J Open

SN - 2044-6055

IS - 5

M1 - e032580

ER -