Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest

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  • Joana Cabral
  • Diego Vidaurre
  • Paulo Marques, Clinical Academic Center (2CA-Braga), 4710-057, Braga, Portugal.
  • ,
  • Ricardo Magalhães, Clinical Academic Center (2CA-Braga), 4710-057, Braga, Portugal.
  • ,
  • Pedro Silva Moreira, Clinical Academic Center (2CA-Braga), 4710-057, Braga, Portugal.
  • ,
  • José Miguel Soares, Clinical Academic Center (2CA-Braga), 4710-057, Braga, Portugal.
  • ,
  • Gustavo Deco, Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Roc Boronat 138, Barcelona 08018, Spain; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, Barcelona 08010, Spain; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; School of Psychological Sciences, Monash University, Melbourne, Clayton VIC 3800, Australia.
  • ,
  • Nuno Sousa, Clinical Academic Center (2CA-Braga), 4710-057, Braga, Portugal.
  • ,
  • Morten L Kringelbach

Growing evidence has shown that brain activity at rest slowly wanders through a repertoire of different states, where whole-brain functional connectivity (FC) temporarily settles into distinct FC patterns. Nevertheless, the functional role of resting-state activity remains unclear. Here, we investigate how the switching behavior of resting-state FC relates with cognitive performance in healthy older adults. We analyse resting-state fMRI data from 98 healthy adults previously categorized as being among the best or among the worst performers in a cohort study of >1000 subjects aged 50+ who underwent neuropsychological assessment. We use a novel approach focusing on the dominant FC pattern captured by the leading eigenvector of dynamic FC matrices. Recurrent FC patterns - or states - are detected and characterized in terms of lifetime, probability of occurrence and switching profiles. We find that poorer cognitive performance is associated with weaker FC temporal similarity together with altered switching between FC states. These results provide new evidence linking the switching dynamics of FC during rest with cognitive performance in later life, reinforcing the functional role of resting-state activity for effective cognitive processing.

Original languageEnglish
JournalScientific Reports
Volume7
Issue1
Pages (from-to)5135
ISSN2045-2322
DOIs
Publication statusPublished - 11 Jul 2017

    Research areas

  • Journal Article

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