Abstract
Background: Obsessive-compulsive Disorder (OCD) affects between 0.25% and 4% of children and adolescents.
Around 40% of youth with OCD continue to meet criteria for OCD well into adulthood. Cognitive behavioral
therapy (CBT) is the recommended first line treatment for pediatric OCD. Consistent with the available followup
research on pediatric OCD, we expected treatment effects, for initial treatment responders, to last
throughout the first year following acute treatment. Methods: This prospective follow-up study was a part of
the Nordic Long-term OCD Treatment Study (NordLOTS) in which 177 responders to 14 weeks of manualized
CBT in an open trial program were assessed six and twelve months after treatment termination. Treatment
response was defined as a Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) total score < 16, and
remission was defined as a CY-BOCS total score ≤10. Results: At one-year follow-up 155 (87.6%) of the original
sample were available for assessment and 142 (91.6%) were still rated as responders. Of these 121 (78.1%)
were in remission. Mixed effects analysis revealed that patients continued to show symptom reduction over
the one year follow-up period (F[2, 313.15] = 11.230, p < 0.001). Twenty-eight patients relapsed (CY-BOCS ≥16)
during the one-year follow-up where of 11 returned to responder status by the 12-month assessment point.
Conclusion: Results of this follow-up study suggest that manualized CBT applied in community settings has
durable effects for initial responders to treatment, and that patients continue to improve during the first year
following acute treatment. Clinical trials registration information: Nordic Long-term Obsessive-Compulsive
Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.
Long-Term Effectiveness of Cognitive Behavioral Treatment (CBT) and Sertraline
Around 40% of youth with OCD continue to meet criteria for OCD well into adulthood. Cognitive behavioral
therapy (CBT) is the recommended first line treatment for pediatric OCD. Consistent with the available followup
research on pediatric OCD, we expected treatment effects, for initial treatment responders, to last
throughout the first year following acute treatment. Methods: This prospective follow-up study was a part of
the Nordic Long-term OCD Treatment Study (NordLOTS) in which 177 responders to 14 weeks of manualized
CBT in an open trial program were assessed six and twelve months after treatment termination. Treatment
response was defined as a Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) total score < 16, and
remission was defined as a CY-BOCS total score ≤10. Results: At one-year follow-up 155 (87.6%) of the original
sample were available for assessment and 142 (91.6%) were still rated as responders. Of these 121 (78.1%)
were in remission. Mixed effects analysis revealed that patients continued to show symptom reduction over
the one year follow-up period (F[2, 313.15] = 11.230, p < 0.001). Twenty-eight patients relapsed (CY-BOCS ≥16)
during the one-year follow-up where of 11 returned to responder status by the 12-month assessment point.
Conclusion: Results of this follow-up study suggest that manualized CBT applied in community settings has
durable effects for initial responders to treatment, and that patients continue to improve during the first year
following acute treatment. Clinical trials registration information: Nordic Long-term Obsessive-Compulsive
Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119.
Long-Term Effectiveness of Cognitive Behavioral Treatment (CBT) and Sertraline
| Original language | English |
|---|---|
| Publication date | 2017 |
| Publication status | Published - 2017 |
| Event | EABCT 2017 - Ljubljana, Slovenia Duration: 13 Sept 2017 → 16 Sept 2017 http://www.eabct2017.org/en/ |
Conference
| Conference | EABCT 2017 |
|---|---|
| Country/Territory | Slovenia |
| City | Ljubljana |
| Period | 13/09/2017 → 16/09/2017 |
| Internet address |