Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy

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DOI

  • Zhenglin Li, Harbin Institute of Technology
  • ,
  • Shaoshan Hu, The Second Affiliated Hospital of Harbin Medical University
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  • Jing Liu, Chinese Academy of Sciences
  • ,
  • Ying Hu, Harbin Institute of Technology
  • ,
  • Lei Chen, The Second Affiliated Hospital of Harbin Medical University
  • ,
  • Tingting Jiang, Harbin Institute of Technology
  • ,
  • Lei Sun, Harbin Institute of Technology
  • ,
  • Ye Sun, Harbin Institute of Technology
  • ,
  • Flemming Besenbacher
  • Chunying Chen, Chinese Academy of Sciences
  • ,
  • Miao Yu, Harbin Institute of Technology

Biocompatible single-component theranostic nanoagents instinctly affording multiple imaging modalities with satisfying therapeutic functions are highly desirable for anticancer treatments. Although cobalt-based phosphides are well-recognized as competent electrocatalysts, their potentials for biomedical applications remain unexplored. In this work, cobalt phosphide nanoparticles (CoP NPs) are developed to be a powerful theranostic agent for multimodal imaging and anticancer photothermal therapy. The uniform CoP NPs in a size of approximate to 21 nm are synthesized via a facile thermal decomposition method, followed by surface modification. The resultant CoP NPs exhibit excellent compatibility and stability in water as well as various physiological solutions. Supported by the good biocompatibility, strong near-infrared absorption, and high photothermal conversion property, significant photothermal effect of the NPs is demonstrated, realizing efficient hyperthermia ablation on cancer cells. Importantly, the CoP NPs have shown considerable capabilities on high-contrast in vitro and in vivo triple-modal imaging, including infrared thermal (IRT), photoacoustic (PA), and T-2-weighted magnetic resonance (MR) imaging. This work has unraveled the promising potentials of CoP-based nanoagent for precise diagnosis and efficient therapy.

Original languageEnglish
Article number1800127
JournalParticle & Particle Systems Characterization
Volume35
Issue8
Number of pages10
ISSN0934-0866
DOIs
Publication statusPublished - 17 Aug 2018

    Research areas

  • cobalt phosphide nanoparticles, magnetic resonance imaging, photoacoustic imaging, photothermal therapy, theranostic nanoagent, PRUSSIAN BLUE NANOPARTICLES, LAYER MOS2 NANOSHEETS, NEAR-INFRARED LIGHT, DRUG-DELIVERY, CANCER-THERAPY, NANOCRYSTALS, ABLATION, GRAPHENE, NANODOTS, PLATFORM

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