Cobalamin Status from Pregnancy to Early Childhood: Lessons from Global Experience

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  • Rima Obeid
  • ,
  • Michelle Murphy, Universitat Rovira i Virgili, Spain
  • Pol Solé-Navais, Universitat Rovira i Virgili, Spain
  • Chittaranjan Yajnik, King Edward Memorial Hospital Research Centre, India

Low cobalamin intake and status during pregnancy or lactation have been linked to adverse maternal and perinatal health outcomes, whereas low cobalamin status during early childhood is associated with impaired development in children. Women who begin pregnancy with depleted stores (low or very low plasma cobalamin) will give birth to depleted infants who are likely to develop deficiency symptoms during the first few weeks or months postpartum. Newly ingested cobalamin during pregnancy and lactation (from diet or supplements) is transferred to the child and is not likely to correct cobalamin status in depleted women. The prevalence of low cobalamin status is high especially in low-income settings or in populations with a low intake of animal products. Folate and cobalamin play interdependent roles in one-carbon metabolism. Although folic acid supplementation during early pregnancy is widely recommended and practiced, cobalamin supplementation during pregnancy and lactation has received little attention. Furthermore, the intake recommendations for pregnant and lactating women and in early life need reevaluation in the light of newly available evidence in the field.

Original languageEnglish
JournalAdvances in Nutrition
Pages (from-to)971-979
Number of pages9
Publication statusPublished - Nov 2017

    Research areas

  • Journal Article, Review

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