Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau

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Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau. / Sørensen, Allan; Jespersen, Sanne; Katzenstein, Terese L; Medina, Candida; Té, David da Silva; Correira, Faustino Gomes; Hviid, Cecilie Juul; Laursen, Alex Lund; Wejse, Christian.

In: Infectious Diseases, Vol. 48, No. 8, 08.2016, p. 604-611.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Sørensen, A, Jespersen, S, Katzenstein, TL, Medina, C, Té, DDS, Correira, FG, Hviid, CJ, Laursen, AL & Wejse, C 2016, 'Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau', Infectious Diseases, vol. 48, no. 8, pp. 604-611. https://doi.org/10.1080/23744235.2016.1180708

APA

Sørensen, A., Jespersen, S., Katzenstein, T. L., Medina, C., Té, D. D. S., Correira, F. G., Hviid, C. J., Laursen, A. L., & Wejse, C. (2016). Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau. Infectious Diseases, 48(8), 604-611. https://doi.org/10.1080/23744235.2016.1180708

CBE

Sørensen A, Jespersen S, Katzenstein TL, Medina C, Té DDS, Correira FG, Hviid CJ, Laursen AL, Wejse C. 2016. Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau. Infectious Diseases. 48(8):604-611. https://doi.org/10.1080/23744235.2016.1180708

MLA

Vancouver

Sørensen A, Jespersen S, Katzenstein TL, Medina C, Té DDS, Correira FG et al. Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau. Infectious Diseases. 2016 Aug;48(8):604-611. https://doi.org/10.1080/23744235.2016.1180708

Author

Sørensen, Allan ; Jespersen, Sanne ; Katzenstein, Terese L ; Medina, Candida ; Té, David da Silva ; Correira, Faustino Gomes ; Hviid, Cecilie Juul ; Laursen, Alex Lund ; Wejse, Christian. / Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau. In: Infectious Diseases. 2016 ; Vol. 48, No. 8. pp. 604-611.

Bibtex

@article{b657a409a6e6404ab3021d2d89e03a15,
title = "Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau",
abstract = "BACKGROUND: Better understanding of HIV-2 infection is likely to affect the patient care in areas where HIV-2 is prevalent. In this study, we aimed to characterize the clinical presentations among HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.METHODS: In a cross-sectional study, newly diagnosed HIV patients attending the HIV outpatient clinic at Hospital Nacional Sim{\~a}o Mendes in Guinea-Bissau were enrolled. Demographical and clinical data were collected and compared between HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.RESULTS: A total of 169 patients (76% HIV-1, 17% HIV-2 and 6% HIV 1/2) were included in the study between 21 March 2012 and 14 December 2012. HIV-1 seropositive patients were younger than HIV-2 and HIV-1/2 seropositive patients, but no difference in sex was observed. Patients with HIV-1 and HIV-1/2 had a lower baseline CD4 cell count than HIV-2 seropositive patients (median CD4 cell count 185, 198 and 404 cells/μl, respectively (p value 0.001 and 0.05). HIV-1 seropositive patients had a lower BMI and a higher prevalence of weight loss, skin rash and productive cough than HIV-2 seropositive patients (p value 0.03, 0.002, 0.03 and 0.04). Only four cases (2%) of pulmonary tuberculosis (TB) were diagnosed. One patient (1/96, 1%) was tested positive for cryptococcal antigen.CONCLUSION: HIV-1 and HIV-1/2 seropositive patients have lower CD4 cell counts than HIV-2 seropositive patients when diagnosed with HIV with only minor clinical and demographic differences among groups. Few patients were diagnosed with TB and cryptococcal disease was not found to be a major opportunistic infection among newly diagnosed HIV patients.",
keywords = "Clinical presentation, Guinea-Bissau, HIV, HIV-2, Sub-Saharan Africa",
author = "Allan S{\o}rensen and Sanne Jespersen and Katzenstein, {Terese L} and Candida Medina and T{\'e}, {David da Silva} and Correira, {Faustino Gomes} and Hviid, {Cecilie Juul} and Laursen, {Alex Lund} and Christian Wejse",
year = "2016",
month = aug,
doi = "10.1080/23744235.2016.1180708",
language = "English",
volume = "48",
pages = "604--611",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "0036-5548",
publisher = "Taylor & Francis ",
number = "8",

}

RIS

TY - JOUR

T1 - Clinical presentation and opportunistic infections in HIV-1, HIV-2 and HIV-1/2 dual seropositive patients in Guinea-Bissau

AU - Sørensen, Allan

AU - Jespersen, Sanne

AU - Katzenstein, Terese L

AU - Medina, Candida

AU - Té, David da Silva

AU - Correira, Faustino Gomes

AU - Hviid, Cecilie Juul

AU - Laursen, Alex Lund

AU - Wejse, Christian

PY - 2016/8

Y1 - 2016/8

N2 - BACKGROUND: Better understanding of HIV-2 infection is likely to affect the patient care in areas where HIV-2 is prevalent. In this study, we aimed to characterize the clinical presentations among HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.METHODS: In a cross-sectional study, newly diagnosed HIV patients attending the HIV outpatient clinic at Hospital Nacional Simão Mendes in Guinea-Bissau were enrolled. Demographical and clinical data were collected and compared between HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.RESULTS: A total of 169 patients (76% HIV-1, 17% HIV-2 and 6% HIV 1/2) were included in the study between 21 March 2012 and 14 December 2012. HIV-1 seropositive patients were younger than HIV-2 and HIV-1/2 seropositive patients, but no difference in sex was observed. Patients with HIV-1 and HIV-1/2 had a lower baseline CD4 cell count than HIV-2 seropositive patients (median CD4 cell count 185, 198 and 404 cells/μl, respectively (p value 0.001 and 0.05). HIV-1 seropositive patients had a lower BMI and a higher prevalence of weight loss, skin rash and productive cough than HIV-2 seropositive patients (p value 0.03, 0.002, 0.03 and 0.04). Only four cases (2%) of pulmonary tuberculosis (TB) were diagnosed. One patient (1/96, 1%) was tested positive for cryptococcal antigen.CONCLUSION: HIV-1 and HIV-1/2 seropositive patients have lower CD4 cell counts than HIV-2 seropositive patients when diagnosed with HIV with only minor clinical and demographic differences among groups. Few patients were diagnosed with TB and cryptococcal disease was not found to be a major opportunistic infection among newly diagnosed HIV patients.

AB - BACKGROUND: Better understanding of HIV-2 infection is likely to affect the patient care in areas where HIV-2 is prevalent. In this study, we aimed to characterize the clinical presentations among HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.METHODS: In a cross-sectional study, newly diagnosed HIV patients attending the HIV outpatient clinic at Hospital Nacional Simão Mendes in Guinea-Bissau were enrolled. Demographical and clinical data were collected and compared between HIV-1, HIV-2 and HIV-1/2 dual seropositive patients.RESULTS: A total of 169 patients (76% HIV-1, 17% HIV-2 and 6% HIV 1/2) were included in the study between 21 March 2012 and 14 December 2012. HIV-1 seropositive patients were younger than HIV-2 and HIV-1/2 seropositive patients, but no difference in sex was observed. Patients with HIV-1 and HIV-1/2 had a lower baseline CD4 cell count than HIV-2 seropositive patients (median CD4 cell count 185, 198 and 404 cells/μl, respectively (p value 0.001 and 0.05). HIV-1 seropositive patients had a lower BMI and a higher prevalence of weight loss, skin rash and productive cough than HIV-2 seropositive patients (p value 0.03, 0.002, 0.03 and 0.04). Only four cases (2%) of pulmonary tuberculosis (TB) were diagnosed. One patient (1/96, 1%) was tested positive for cryptococcal antigen.CONCLUSION: HIV-1 and HIV-1/2 seropositive patients have lower CD4 cell counts than HIV-2 seropositive patients when diagnosed with HIV with only minor clinical and demographic differences among groups. Few patients were diagnosed with TB and cryptococcal disease was not found to be a major opportunistic infection among newly diagnosed HIV patients.

KW - Clinical presentation

KW - Guinea-Bissau

KW - HIV

KW - HIV-2

KW - Sub-Saharan Africa

UR - http://www.scopus.com/inward/record.url?scp=85009250575&partnerID=8YFLogxK

U2 - 10.1080/23744235.2016.1180708

DO - 10.1080/23744235.2016.1180708

M3 - Journal article

C2 - 27163507

VL - 48

SP - 604

EP - 611

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

IS - 8

ER -