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Clinical Olfactory Working Group Consensus Statement on the Treatment of Post Infectious Olfactory Dysfunction

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

  • Alfred B Addison, East Sussex North Essex Foundation Trust
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  • Billy Wong, East Sussex North Essex Foundation Trust
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  • Tanzime Ahmed, East Sussex North Essex Foundation Trust
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  • Alberto Macchi, ENT University of Insubria
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  • Iordanis Konstantinidis, Aristotle Univ Thessaloniki, Aristotle University of Thessaloniki, Ahepa University Hospital, Dept Cardiol 1, AHEPA Univ Hosp
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  • Caroline Huart, Department of Psychology and Neuroscience Institute of Turin, University of Turin & National Institute Neuroscience, Turin
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  • Johannes Frasnelli, Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia REsearch and Center for Neuropsychiatric Schizophrenia Research, Psychiatric Center Glostrup, Glostrup
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  • Alexander W Fjaeldstad
  • Vijay R Ramakrishnan, Anschutz Medical Campus, University of Colorado Cancer Center, Colorado, USA
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  • Philippe Rombaux, Department of Psychology and Neuroscience Institute of Turin, University of Turin & National Institute Neuroscience, Turin
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  • Katherine L Whitcroft, RAS - Institute of Philosophy
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  • Eric H Holbrook, Schepens Eye Research Institute/Massachusetts Eye and Ear
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  • Sophia C Poletti, Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; and.
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  • Julien W Hsieh, Geneva University Hospitals, Geneva, Switzerland.
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  • Basile N Landis, Geneva University Hospitals, Geneva, Switzerland.
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  • James Boardman, Fifth Sense
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  • Antje Welge-Lüssen, Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland.
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  • Devina Maru, Royal College of General Practitioners
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  • Thomas Hummel, Smell & Taste Clinic, Department of ORL, TU Dresden, Germany.
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  • Carl M Philpott, Univ East Anglia, University of East Anglia, Norwich Med Sch

BACKGROUND: Respiratory tract viruses are the second most common cause for olfactory dysfunction. As we learn more about the effects of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), with the recognition that olfactory dysfunction is a key symptom of this disease process, there is now a greater need for evidence-based management for post infectious olfactory dysfunction (PIOD).

OBJECTIVE: To provide an evidence based practical guide to the management of PIOD (including post-covid cases) for both primary care practitioners and hospital specialists.

METHODS: A systematic review was performed on the treatment options available for the management of PIOD. The written systematic review was then circulated among the members of the Clinical Olfactory Working Group (COWoG) for their perusal prior to round table expert discussion of the treatment options. The group also undertook a survey to determine their current clinical practice with regards to treatment of PIOD.

RESULTS: The search resulted in 467 citations from which 107 articles were fully reviewed and analysed for eligibility; 40 citations fulfilled the inclusion criteria, 11 of which were randomised controlled trials. In total, 15 of the articles specifically looked at PIOD whilst the other 25 included other aetiologies for olfactory dysfunction.

CONCLUSIONS: The COWoG members made an overwhelming recommendation for olfactory training and none recommended monocycline antibiotics. The diagnostic role of oral steroids is discussed and there were some in favour of vitamin A drops. Further research is needed to confirm the place of other therapeutic options.

Original languageEnglish
JournalJournal of Allergy and Clinical Immunology
Volume147
Issue5
Pages (from-to)1704-1719
Number of pages16
ISSN0091-6749
DOIs
Publication statusPublished - May 2021

    Research areas

  • COVID-19, Olfaction, anosmia, hyposmia, olfactory disorders, parosmia therapy, viral infections

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